Phenotypes associated with this allele

• Allele Symbol: Hprt1^{tm1(ACTB-Opa1)Lsc}
• Allele Name: targeted mutation 1, Luca Scorrano
• Allele ID: MGI:5605470
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Hprt1^tm1(ACTB-Opa1)Lsc/Y	involves: 129 * C57BL/6 * C57BL/6J	MGI:5605474

Genotype
MGI:5605474

ot1

• Allelic Composition: Hprt1^{tm1(ACTB-Opa1)Lsc}/Y
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial crista morphology ( J:214492 )

♂ • liver mitochondria cristae are tighter

abnormal mitochondrial physiology ( J:214492 )

♂ • mice show increased respiratory chain supercomplex levels in liver mitochondria

homeostasis/metabolism

decreased susceptibility to injury ( J:214492 )

♂ • mice are resistant to different forms of tissue damage

growth/size/body

growth/size/body region phenotype ( J:214492 )

♂N • mice are viable, fertile, and grow normally