mortality/aging
• embryonic lethal, with most embryos dying between E10.5 and E11.5
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Allele Symbol Allele Name Allele ID |
Ryr2tm2.1Swch targeted mutation 2.1, S R Wayne Chen MGI:5605476 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• embryonic lethal, with most embryos dying between E10.5 and E11.5
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• elevation of extracellular calcium or application of isoproterenol results in very few or no calcium waves in intact hearts unlike in wild-type mice which show increased frequency of spontaneous calcium waves
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• the L-type calcium channel current in cardiomyocytes is increased, resulting in a reduced excitation-contraction coupling gain
• the time to the peak of the calcium transient is increased in cardiomyocytes, whereas late decay times are shorter
• however, the rate of decay of caffeine-induced calcium transients is not different from wild-type cardiomyocytes
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• cardiomyocytes exhibit reduced propensity for spontaneous store overload-induced calcium release (SOICR)
• sarcoplasmic reticulum calcium content is greater in cardiomyocytes than in wild-type cells when bathed at 5 mM extracellular calcium to overload the sarcoplasmic reticulum, however sarcoplasmic reticulum calcium content under nonoverload conditions is not affected
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• the L-type calcium channel current in cardiomyocytes is increased, resulting in a reduced excitation-contraction coupling gain
• the time to the peak of the calcium transient is increased in cardiomyocytes, whereas late decay times are shorter
• however, the rate of decay of caffeine-induced calcium transients is not different from wild-type cardiomyocytes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are resistant to catecholaminergic polymorphic ventricular tachycardia induced by the administration of caffeine and epinephrine
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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