Phenotypes associated with this allele

• Allele Symbol: Rgs4^tm1Sdlk
• Allele Name: targeted mutation 1, Andrew Siedlecki
• Allele ID: MGI:5605686
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rgs4^tm1Sdlk/Rgs4^tm1Sdlk Tg(Myh11-icre/ERT2)1Soff/?	involves: FVB/N	MGI:5605986

Genotype
MGI:5605986

cn1

• Allelic Composition: Rgs4^tm1Sdlk/Rgs4^tm1Sdlk; Tg(Myh11-icre/ERT2)1Soff/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:215588 )

• following 25 minute bilateral ischemic kidney injury (25BI), cumulative survival is decreased as compared to controls

hematopoietic system

abnormal macrophage chemotaxis ( J:215588 )

• increased numbers of macrophages localize to injured kidneys 18 hours after 10 minute unilateral kidney injury as compared to controls

homeostasis/metabolism

increased circulating creatinine level ( J:215588 )

• serum creatinine levels are increased 88% 48 hours after 25BI as compared to controls

immune system

abnormal macrophage chemotaxis ( J:215588 )

• increased numbers of macrophages localize to injured kidneys 18 hours after 10 minute unilateral kidney injury as compared to controls

cellular

abnormal macrophage chemotaxis ( J:215588 )

• increased numbers of macrophages localize to injured kidneys 18 hours after 10 minute unilateral kidney injury as compared to controls

renal/urinary system

abnormal renal tubule morphology ( J:215588 )

• tubular injury is more extensive 24 hours after 25BI as compared to controls