All Phenotypes Wnt5a<tm1.1Krvl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wnt5a^tm1.1Krvl
targeted mutation 1.1, Rejji Kuruvilla
MGI:5605689

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt5a^tm1.1Krvl/Wnt5a^tm1.1Krvl	involves: 129S6/SvEvTac * C57BL/6	MGI:5605988
cn2	Wnt5a^tm1Amc/Wnt5a^tm1.1Krvl H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J	MGI:5605991
cn3	Wnt5a^tm1.1Krvl/Wnt5a^tm1.1Krvl Tg(Th-cre)#Gsat/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5607432

Allelic Composition	Wnt5a^tm1.1Krvl/Wnt5a^tm1.1Krvl
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt5a^tm1.1Krvl mutation (1 available); any Wnt5a mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:196291 )

• mice are viable and fertile

Allelic Composition	Wnt5a^tm1Amc/Wnt5a^tm1.1Krvl H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Wnt5a^tm1.1Krvl mutation (1 available); any Wnt5a mutation (42 available)
Wnt5a^tm1Amc mutation (1 available); any Wnt5a mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:196291 )

• pups die within a few hours of birth

nervous system

increased neuron apoptosis ( J:196291 )

• increased neuron apoptosis observed in superior cervical ganglia

abnormal axon extension ( J:196291 )

• defects in extension and branching of sympathetic axons are observed in salivary glands, thymus, heart, spleen and bladder at E16.5

abnormal sympathetic neuron innervation pattern ( J:196291 )

• incomplete innervation in paravertebral sympathetic ganglia and prevertebral ganglia

• sympathetic axons in spleen extend to target, but fail to grow and arborize spleen parenchyma

craniofacial

abnormal craniofacial morphology ( J:196291 )

• pups exhibit craniofacial abnormalities

cellular

increased neuron apoptosis ( J:196291 )

• increased neuron apoptosis observed in superior cervical ganglia

abnormal axon extension ( J:196291 )

• defects in extension and branching of sympathetic axons are observed in salivary glands, thymus, heart, spleen and bladder at E16.5

Allelic Composition	Wnt5a^tm1.1Krvl/Wnt5a^tm1.1Krvl Tg(Th-cre)#Gsat/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Th-cre)#Gsat mutation (0 available)
Wnt5a^tm1.1Krvl mutation (1 available); any Wnt5a mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal superior cervical ganglion morphology ( J:196291 )

abnormal sympathetic neuron innervation pattern ( J:196291 )

• reduced innervation of peripheral tissues

decreased neuron number ( J:196291 )

• 30% decrease in numbers of superior cervical ganglia neurons by P7

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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