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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Klrk1tm2.1Bpol
targeted mutation 2.1, Bojan Polic
MGI:5605730
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Klrk1tm2.1Bpol/Klrk1tm2.1Bpol Not Specified MGI:5605731


Genotype
MGI:5605731
hm1
Allelic
Composition		 Klrk1tm2.1Bpol/Klrk1tm2.1Bpol
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klrk1tm2.1Bpol mutation (0 available); any Klrk1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal NK cell differentiation ( J:215590 )
• mice show alterations in cell surface marker expression and maturation stages on NK cell subsets
• reduction of the NK cell population expressing c-Kit in the spleen
• reduction of the NK cell population expressing Ly49A in the spleen

immune system
abnormal NK cell differentiation ( J:215590 )
• mice show alterations in cell surface marker expression and maturation stages on NK cell subsets
• reduction of the NK cell population expressing c-Kit in the spleen
• reduction of the NK cell population expressing Ly49A in the spleen
decreased susceptibility to Herpesvirales infection ( J:215590 )
• mice are better able to control murine cytomegalovirus (MCMV) infection than wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory