mortality/aging
• early blastocysts are present at lower than expected Mendelian ratios at E3.5 (16% versus 25%); no embryos or excess resorption sites are observed at E7.5
|
embryo
• limited or no primitive endoderm (PrE) cells are observed after 3 days in culture
|
• although blastocysts hatch from the zona pellucida and form outgrowths with apparent inner cell mass, limited or no trophectoderm is observed after 3 days in culture
|