Phenotypes associated with this allele

• Allele Symbol: Atp2b1^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5605735
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp2b1^tm1b(KOMP)Wtsi/Atp2b1^tm1b(KOMP)Wtsi	C57BL/6N-Atp2b1^tm1b(KOMP)Wtsi/Tcp	MGI:5756751
ht2	Atp2b1^tm1b(KOMP)Wtsi/Atp2b1^+	C57BL/6N-Atp2b1^tm1b(KOMP)Wtsi/Tcp	MGI:5756750

Genotype
MGI:5756751

hm1

• Allelic Composition: Atp2b1^{tm1b(KOMP)Wtsi}/Atp2b1^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Atp2b1^{tm1b(KOMP)Wtsi}/Tcp
• Cell Lines: EPD0797_1_C06

Data Sources

IMPC Data for Atp2b1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Atp2b1^{tm1b(KOMP)Wtsi}/Atp2b1^{tm1b(KOMP)Wtsi} mice exhibit embryonic lethality, with embryos seen at E3.5 as early blalstocysts but no embryos at E7.5. Blastocysts grown in vitro hatch from the zona pellucida and form outgrowths with an inner cell mass but limited/no trophectoderm or primitive cells.

embryo

absent primitive endoderm ( J:279207 )

• limited or no primitive endoderm (PrE) cells are observed after 3 days in culture

absent trophectoderm ( J:279207 )

• although blastocysts hatch from the zona pellucida and form outgrowths with apparent inner cell mass, limited or no trophectoderm is observed after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

preweaning lethality, complete penetrance ( J:211773 )

♀

IMPC - UCD

embryonic lethality before implantation, complete penetrance ( J:279207 )

• early blastocysts are present at E3.5 (16% versus expected 25%, n=38); no embryos or excess resorption sites are observed at E7.5

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:5756750

ht2

• Allelic Composition: Atp2b1^{tm1b(KOMP)Wtsi}/Atp2b1⁺
• Genetic Background: C57BL/6N-Atp2b1^{tm1b(KOMP)Wtsi}/Tcp
• Cell Lines: EPD0797_1_C06

Data Sources

IMPC Data for Atp2b1

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - UCD

homeostasis/metabolism

decreased circulating calcium level ( J:211773 )

IMPC - UCD

integument

abnormal vibrissa morphology ( J:211773 )

♀

IMPC - UCD

absent vibrissae ( J:211773 )

♀

IMPC - UCD

reproductive system

abnormal epididymis morphology ( J:211773 )

♂

IMPC - UCD

enlarged epididymis ( J:211773 )

♂

IMPC - UCD