All Phenotypes Rnf216<tm1b(EUCOMM)Wtsi> MGI Mouse

reproductive system phenotype ( J:274674 )

N	• female fertility is normal

decreased male germ cell number ( J:274674 )

• H&E staining revealed severe germ cell loss in adult testes

increased male germ cell apoptosis ( J:274674 )

• germ cell degeneration of spermatocytes begins at around 2 weeks of age and peaks at 3 to 4 weeks

• TUNEL analysis of testis sections revealed increased germ cell apoptosis at 3 weeks of age, correlating with the onset of germ cell degeneration

seminiferous tubule degeneration ( J:274674 )

• seminiferous tubules exhibit a range of germ cell degeneration phenotypes, ranging from degenerating spermatocytes or round spermatids to Sertoli-cell-only tubules

small testis ( J:274674 )

• adult testis size is significantly smaller than that of heterozygous controls

decreased testis weight ( J:274674 )

• adult testis weight is significantly lower than that of heterozygous controls

abnormal spermatogenesis ( J:274674 )

• germ cell development is disrupted

abnormal spermatid morphology ( J:274674 )

• very few elongated spermatids are generated

abnormal spermatocyte morphology ( J:274674 )

• degeneration of spermatocytes begins at around 2 weeks of age and peaks at 3 to 4 weeks

abnormal epididymis morphology ( J:274674 )

• cauda epididymides lack normal spermatozoa and contain cellular debris

male infertility ( J:274674 )

• males are sterile