Phenotypes associated with this allele

• Allele Symbol: Fam210a^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5605775
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fam210a^tm1b(EUCOMM)Wtsi/Fam210a^tm1b(EUCOMM)Wtsi	C57BL/6N-Fam210a^tm1b(EUCOMM)Wtsi/Tcp	MGI:5757082
hm2	Fam210a^tm1b(EUCOMM)Wtsi/Fam210a^tm1b(EUCOMM)Wtsi	involves: BALB/cJ * C57BL/6N	MGI:6159283
ht3	Fam210a^tm1b(EUCOMM)Wtsi/Fam210a^+	C57BL/6N-Fam210a^tm1b(EUCOMM)Wtsi/Tcp	MGI:5797526
ht4	Fam210a^tm1b(EUCOMM)Wtsi/Fam210a^+	involves: BALB/cJ * C57BL/6N	MGI:6159282

Genotype
MGI:5757082

hm1

• Allelic Composition: Fam210a^{tm1b(EUCOMM)Wtsi}/Fam210a^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Fam210a^{tm1b(EUCOMM)Wtsi}/Tcp
• Cell Lines: EPD0690_3_B07

Data Sources

IMPC Data for Fam210a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - TCP

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

Genotype
MGI:6159283

hm2

• Allelic Composition: Fam210a^{tm1b(EUCOMM)Wtsi}/Fam210a^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: BALB/cJ * C57BL/6N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:261817 )

• mice died shortly after E9.5

Genotype
MGI:5797526

ht3

• Allelic Composition: Fam210a^{tm1b(EUCOMM)Wtsi}/Fam210a⁺
• Genetic Background: C57BL/6N-Fam210a^{tm1b(EUCOMM)Wtsi}/Tcp
• Cell Lines: EPD0690_3_B07

Data Sources

IMPC Data for Fam210a

hematopoietic system

increased mean corpuscular volume ( J:211773 )

♂

IMPC - TCP

homeostasis/metabolism

increased circulating triglyceride level ( J:211773 )

IMPC - TCP

Genotype
MGI:6159282

ht4

• Allelic Composition: Fam210a^{tm1b(EUCOMM)Wtsi}/Fam210a⁺
• Genetic Background: involves: BALB/cJ * C57BL/6N

skeleton

increased osteoclast cell number ( J:261817 )

decreased bone mineral density ( J:261817 )

• in cortical bones

abnormal compact bone morphology ( J:261817 )

• mice exhibit increased cortical porosity compared with control mice

decreased compact bone volume ( J:261817 )

decreased compact bone thickness ( J:261817 )

decreased bone ossification ( J:261817 )

• in cortical bones

decreased bone strength ( J:261817 )

immune system

increased osteoclast cell number ( J:261817 )

hematopoietic system

increased osteoclast cell number ( J:261817 )