Phenotypes associated with this allele

• Allele Symbol: Pdia6^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5605786
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdia6^tm1b(EUCOMM)Hmgu/Pdia6^tm1b(EUCOMM)Hmgu	C57BL/6N-Pdia6^tm1b(EUCOMM)Hmgu/Ieg	MGI:6263127
ht2	Pdia6^tm1b(EUCOMM)Hmgu/Pdia6^+	C57BL/6N-Pdia6^tm1b(EUCOMM)Hmgu/Ieg	MGI:6263126

Genotype
MGI:6263127

hm1

• Allelic Composition: Pdia6^{tm1b(EUCOMM)Hmgu}/Pdia6^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Pdia6^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0530_2_F02

Data Sources

IMPC Data for Pdia6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:6263126

ht2

• Allelic Composition: Pdia6^{tm1b(EUCOMM)Hmgu}/Pdia6⁺
• Genetic Background: C57BL/6N-Pdia6^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0530_2_F02

Data Sources

IMPC Data for Pdia6

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - HMGU

behavior/neurological

abnormal gait ( J:211773 )

♀

IMPC - HMGU

endocrine/exocrine glands

enlarged thyroid gland ( J:211773 )

♀

IMPC - HMGU

hematopoietic system

decreased CD4-positive NK T cell number ( J:211773 )

♀

IMPC - HMGU

immune system

decreased CD4-positive NK T cell number ( J:211773 )

♀

IMPC - HMGU

enlarged lymph nodes ( J:211773 )

♀

IMPC - HMGU