Phenotypes associated with this allele

• Allele Symbol: Ash1l^{tm2b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5605812
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ash1l^tm2b(EUCOMM)Hmgu/Ash1l^tm2b(EUCOMM)Hmgu	C57BL/6N-Ash1l^tm2b(EUCOMM)Hmgu/Nju	MGI:5767571
ht2	Ash1l^tm2b(EUCOMM)Hmgu/Ash1l^+	C57BL/6N-Ash1l^tm2b(EUCOMM)Hmgu/Nju	MGI:5797382

Genotype
MGI:5767571

hm1

• Allelic Composition: Ash1l^{tm2b(EUCOMM)Hmgu}/Ash1l^{tm2b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ash1l^{tm2b(EUCOMM)Hmgu}/Nju
• Cell Lines: HEPD0792_8_C04

Data Sources

IMPC Data for Ash1l

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - MARC

Genotype
MGI:5797382

ht2

• Allelic Composition: Ash1l^{tm2b(EUCOMM)Hmgu}/Ash1l⁺
• Genetic Background: C57BL/6N-Ash1l^{tm2b(EUCOMM)Hmgu}/Nju
• Cell Lines: HEPD0792_8_C04

Data Sources

IMPC Data for Ash1l

behavior/neurological

impaired pupillary reflex ( J:211773 )

♀

IMPC - MARC

increased grip strength ( J:211773 )

IMPC - MARC

cardiovascular system

increased heart weight ( J:211773 )

♂

IMPC - MARC

growth/size/body

increased heart weight ( J:211773 )

♂

IMPC - MARC

hematopoietic system

increased basophil cell number ( J:211773 )

IMPC - MARC

increased eosinophil cell number ( J:211773 )

IMPC - MARC

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - MARC

immune system

increased basophil cell number ( J:211773 )

IMPC - MARC

increased eosinophil cell number ( J:211773 )

IMPC - MARC

integument

abnormal coat appearance ( J:211773 )

♂

IMPC - MARC

vision/eye

impaired pupillary reflex ( J:211773 )

♀

IMPC - MARC