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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gpr139tm1.1(KOMP)Vlcg
targeted mutation 1.1, Velocigene
MGI:5605824
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gpr139tm1.1(KOMP)Vlcg/Gpr139tm1.1(KOMP)Vlcg C57BL/6N-Gpr139tm1.1(KOMP)Vlcg/Ucd MGI:6262559
hm2
Gpr139tm1.1(KOMP)Vlcg/Gpr139tm1.1(KOMP)Vlcg involves: C57BL/6NTac MGI:6473973


Genotype
MGI:6262559
hm1
Allelic
Composition
Gpr139tm1.1(KOMP)Vlcg/Gpr139tm1.1(KOMP)Vlcg
Genetic
Background
C57BL/6N-Gpr139tm1.1(KOMP)Vlcg/Ucd
Cell Lines 10338B-A5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr139tm1.1(KOMP)Vlcg mutation (1 available); any Gpr139 mutation (27 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6473973
hm2
Allelic
Composition
Gpr139tm1.1(KOMP)Vlcg/Gpr139tm1.1(KOMP)Vlcg
Genetic
Background
involves: C57BL/6NTac
Cell Lines 10338B-A5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr139tm1.1(KOMP)Vlcg mutation (1 available); any Gpr139 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• basal firing rates are selectively increased in locus coeruleus (LC) neurons but not in medial habenula (MHb) neurons
• firing of MHb neurons is significantly reduced by DAMGO (a synthetic enkephalin-mimetic peptide) at a low concentration (0.3 um), which has no significant effect in wild-type MHb neurons
• MHb neurons show a significantly greater net inhibition of neuronal firing by DAMGO both at a low (0.3 um) and high (1 uM) concentration
• following washout of DAMGO (1 uM), recovery kinetics of MHb neurons is significantly slower than that in wild-type MHb neurons, indicating greater susceptibility to opioid inhibition
• firing of LC neurons is significantly reduced by morphine at 0.1 um, which has no significant effect in wild-type LC neurons

behavior/neurological
N
• at ~4 months of age, mice exhibit normal baseline learning, nociception, locomotor activity, habituation to an unfamiliar environment and motor coordination relative to wild-type controls
• mice exhibit significantly reduced withdrawal signs (diarrhea, jumps, dog shakes, paw tremor, back walking, tremor and ptosis) and weight loss due to naloxone-precipitated somatic withdrawal after chronic morphine exposure
• in a conditioned place preference paradigm, mice exhibit augmented responses to the rewarding effects of morphine, in agreement with increased opioid sensitivity of MHb neurons
• mice exhibit enhanced morphine-induced analgesia in thermal (hot plate and tail immersion) and mechanical (Von Frey) pain paradigms, as shown by increases in both maximal response and effect duration across multiple morphine doses
• administration of JNJ-63533054 (a GPR139 agonist) fails to diminish morphine-induced (10mg/kg) analgesia in a dose-dependent manner in the thermal and mechanical pain paradigms, unlike in wild-type control mice

growth/size/body
N
• at ~4 months of age, mice exhibit normal health, body weight and body composition relative to wild-type controls





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory