Phenotypes associated with this allele

• Allele Symbol: Cyp17a1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5605834
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp17a1^tm1b(EUCOMM)Wtsi/Cyp17a1^tm1b(EUCOMM)Wtsi	C57BL/6N-Cyp17a1^tm1b(EUCOMM)Wtsi/Nju	MGI:5756939

Genotype
MGI:5756939

hm1

• Allelic Composition: Cyp17a1^{tm1b(EUCOMM)Wtsi}/Cyp17a1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Cyp17a1^{tm1b(EUCOMM)Wtsi}/Nju
• Cell Lines: EPD0214_2_B11

Data Sources

IMPC Data for Cyp17a1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - MARC

behavior/neurological

decreased grip strength ( J:211773 )

♀

IMPC - MARC

decreased locomotor activity ( J:211773 )

♀

IMPC - MARC

abnormal vocalization ( J:211773 )

♂

IMPC - MARC

cardiovascular system

decreased heart weight ( J:211773 )

♀

IMPC - MARC

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - MARC

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - MARC

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

♂

IMPC - MARC

increased blood urea nitrogen level ( J:211773 )

♀

IMPC - MARC

increased fasting circulating glucose level ( J:211773 )

IMPC - MARC

increased circulating cholesterol level ( J:211773 )

IMPC - MARC

increased circulating HDL cholesterol level ( J:211773 )

IMPC - MARC

decreased circulating phosphate level ( J:211773 )

♀

IMPC - MARC

increased circulating alkaline phosphatase level ( J:211773 )

♂

IMPC - MARC

improved glucose tolerance ( J:211773 )

♂

IMPC - MARC

reproductive system

abnormal male genitalia morphology ( J:211773 )

IMPC - MARC

absent external male genitalia ( J:211773 )

IMPC - MARC

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - MARC

decreased bone mineral content ( J:211773 )

IMPC - MARC

decreased bone mineral density ( J:211773 )

IMPC - MARC