Phenotypes associated with this allele

• Allele Symbol: Bach2^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5605836
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bach2^tm1b(EUCOMM)Wtsi/Bach2^tm1b(EUCOMM)Wtsi	C57BL/6N-Bach2^tm1b(EUCOMM)Wtsi/Ieg	MGI:6261950

Genotype
MGI:6261950

hm1

• Allelic Composition: Bach2^{tm1b(EUCOMM)Wtsi}/Bach2^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Bach2^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0689_1_H02

Data Sources

IMPC Data for Bach2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - HMGU

decreased food intake ( J:211773 )

IMPC - HMGU

limb grasping ( J:211773 )

♂

IMPC - HMGU

increased grip strength ( J:211773 )

♂

IMPC - HMGU

decreased vertical activity ( J:211773 )

IMPC - HMGU

hyperactivity ( J:211773 )

IMPC - HMGU

hematopoietic system

increased granulocyte number ( J:211773 )

♂

IMPC - HMGU

increased eosinophil cell number ( J:211773 )

♀

IMPC - HMGU

decreased CD11b-high dendritic cell number ( J:211773 )

IMPC - HMGU

decreased B cell number ( J:211773 )

IMPC - HMGU

decreased transitional stage B cell number ( J:211773 )

♀

IMPC - HMGU

decreased B-1a cell number ( J:211773 )

♀

IMPC - HMGU

decreased B-2 B cell number ( J:211773 )

IMPC - HMGU

decreased follicular B cell number ( J:211773 )

IMPC - HMGU

decreased marginal zone B cell number ( J:211773 )

IMPC - HMGU

decreased Ly6C-positive immature NK cell number ( J:211773 )

♀

IMPC - HMGU

decreased Ly6C-positive mature NK cell number ( J:211773 )

♀

IMPC - HMGU

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

♀

IMPC - HMGU

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - HMGU

decreased NK T cell number ( J:211773 )

♀

IMPC - HMGU

decreased CD4-negative NK T cell number ( J:211773 )

IMPC - HMGU

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

♀

IMPC - HMGU

increased NK T cell number ( J:211773 )

♂

IMPC - HMGU

increased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - HMGU

increased monocyte cell number ( J:211773 )

♂

IMPC - HMGU

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

IMPC - HMGU

decreased circulating glucose level ( J:211773 )

IMPC - HMGU

increased circulating alkaline phosphatase level ( J:211773 )

♂

IMPC - HMGU

increased circulating amylase level ( J:211773 )

♂

IMPC - HMGU

increased circulating aspartate transaminase level ( J:211773 )

♀

IMPC - HMGU

increased circulating unsaturated transferrin level ( J:211773 )

IMPC - HMGU

decreased respiratory quotient ( J:211773 )

IMPC - HMGU

immune system

immune system phenotype ( J:211773 )

IMPC - HMGU

increased granulocyte number ( J:211773 )

♂

IMPC - HMGU

increased eosinophil cell number ( J:211773 )

♀

IMPC - HMGU

decreased CD11b-high dendritic cell number ( J:211773 )

IMPC - HMGU

decreased B cell number ( J:211773 )

IMPC - HMGU

decreased transitional stage B cell number ( J:211773 )

♀

IMPC - HMGU

decreased B-1a cell number ( J:211773 )

♀

IMPC - HMGU

decreased B-2 B cell number ( J:211773 )

IMPC - HMGU

decreased follicular B cell number ( J:211773 )

IMPC - HMGU

decreased marginal zone B cell number ( J:211773 )

IMPC - HMGU

decreased Ly6C-positive immature NK cell number ( J:211773 )

♀

IMPC - HMGU

decreased Ly6C-positive mature NK cell number ( J:211773 )

♀

IMPC - HMGU

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

♀

IMPC - HMGU

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - HMGU

decreased NK T cell number ( J:211773 )

♀

IMPC - HMGU

decreased CD4-negative NK T cell number ( J:211773 )

IMPC - HMGU

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

♀

IMPC - HMGU

increased NK T cell number ( J:211773 )

♂

IMPC - HMGU

increased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - HMGU

increased monocyte cell number ( J:211773 )

♂

IMPC - HMGU

limbs/digits/tail

short tibia ( J:211773 )

♀

IMPC - HMGU

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU

decreased prepulse inhibition ( J:211773 )

IMPC - HMGU

respiratory system

increased pulmonary respiratory rate ( J:211773 )

IMPC - HMGU

skeleton

short tibia ( J:211773 )

♀

IMPC - HMGU

decreased bone mineral density ( J:211773 )

♀

IMPC - HMGU

vision/eye

abnormal optic disk morphology ( J:211773 )

IMPC - HMGU