Phenotypes associated with this allele

• Allele Symbol: Loricrin^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5605843
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Loricrin^tm1.1(KOMP)Vlcg/Loricrin^tm1.1(KOMP)Vlcg	C57BL/6N-Loricrin^tm1.1(KOMP)Vlcg/Ucd	MGI:5639392
ht2	Loricrin^tm1.1(KOMP)Vlcg/Loricrin^+	C57BL/6N-Loricrin^tm1.1(KOMP)Vlcg/Ucd	MGI:5706031

Genotype
MGI:5639392

hm1

• Allelic Composition: Loricrin^{tm1.1(KOMP)Vlcg}/Loricrin^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Loricrin^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 11607A-B6

Data Sources

IMPC Data for Loricrin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

growth/size/body

increased kidney weight ( J:211773 )

♂

IMPC - UCD

increased spleen weight ( J:211773 )

♂

IMPC - UCD

hematopoietic system

increased spleen weight ( J:211773 )

♂

IMPC - UCD

immune system

increased spleen weight ( J:211773 )

♂

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

♂

IMPC - UCD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - UCD

renal/urinary system

increased kidney weight ( J:211773 )

♂

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

Genotype
MGI:5706031

ht2

• Allelic Composition: Loricrin^{tm1.1(KOMP)Vlcg}/Loricrin⁺
• Genetic Background: C57BL/6N-Loricrin^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 11607A-B6

Data Sources

IMPC Data for Loricrin

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - UCD

enlarged heart ( J:211773 )

♂

IMPC - UCD

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - UCD

increased kidney weight ( J:211773 )

♂

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

homeostasis/metabolism

improved glucose tolerance ( J:211773 )

♂

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

integument

abnormal vibrissa morphology ( J:211773 )

♀

IMPC - UCD

abnormal skin morphology ( J:211773 )

♂

IMPC - UCD

liver/biliary system

abnormal liver morphology ( J:211773 )

♂

IMPC - UCD

renal/urinary system

increased kidney weight ( J:211773 )

♂

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

abnormal uterus morphology ( J:211773 )

♀

IMPC - UCD

enlarged uterus ( J:211773 )

♀

IMPC - UCD