Phenotypes associated with this allele

• Allele Symbol: Dolk^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5605979
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dolk^em1(IMPC)J/Dolk^em1(IMPC)J	C57BL/6NJ-Dolk^em1(IMPC)J/J	MGI:5883989

Genotype
MGI:5883989

hm1

• Allelic Composition: Dolk^em1(IMPC)J/Dolk^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Dolk^em1(IMPC)J/J

Data Sources

IMPC Data for Dolk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dolk^em1(IMPC)J/Dolk^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller, with a rudimentary egg cylinder, and failure of primitive streak formation and gastrulation.

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

decreased egg cylinder size ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered in expected Mendelian ratios at E7.5 but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5