All Phenotypes Ryr2<tm3.1Swch> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ryr2^tm3.1Swch
targeted mutation 3.1, S R Wayne Chen
MGI:5606046

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ryr2^tm3.1Swch/Ryr2^tm3.1Swch	involves: 129S1/Sv * 129X1/SvJ	MGI:5606047
ht2	Ryr2^tm3.1Swch/Ryr2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5606048
cn3	Ryr2^tm1Krbr/Ryr2^tm3.1Swch A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5606049

Allelic Composition	Ryr2^tm3.1Swch/Ryr2^tm3.1Swch
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2^tm3.1Swch mutation (0 available); any Ryr2 mutation (325 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:215190 )

• embryonic lethal, time not specified

Allelic Composition	Ryr2^tm3.1Swch/Ryr2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2^tm3.1Swch mutation (0 available); any Ryr2 mutation (325 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardial fiber physiology ( J:215190 )

• the time-to-peak and time-to-50% decay of calcium release evoked by depolarization is slightly, but significantly, increased in cardiomyocytes

• however, mice do not exhibit stress-induced (by caffeine or epinephrine) ventricular tachyarrhythmias at young or older ages

Allelic Composition	Ryr2^tm1Krbr/Ryr2^tm3.1Swch A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mutation (5 available); any A1cf mutation (39 available)
Ryr2^tm1Krbr mutation (1 available); any Ryr2 mutation (325 available)
Ryr2^tm3.1Swch mutation (0 available); any Ryr2 mutation (325 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:215190 )

• mice die starting around 11 days post tamoxifen injection, with most dying by day 14

cardiovascular system

decreased heart rate ( J:215190 )

• 12 days post tamoxifen treatment, mice exhibit a reduced basal heart rate

• tamoxifen treated mice, however, do not exhibit stress-induced (by caffeine or epinephrine) ventricular tachyarrhythmias at young or older ages

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