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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Diaph2tm1.2Sna
targeted mutation 1.2, Shuh Narumiya
MGI:5606179
Summary 4 genotypes


Genotype
MGI:5606186
hm1
Allelic
Composition		 Diaph2tm1.2Sna/Diaph2tm1.2Sna
Genetic
Background		 B6N.Cg-Diaph2tm1.2Sna
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diaph2tm1.2Sna mutation (0 available); any Diaph2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:215740 )
• homozygotes appear to develop normally




Genotype
MGI:5606188
cx2
Allelic
Composition		 Diaph1tm1.1Sna/Diaph1tm1.1Sna
Diaph2tm1.2Sna/Diaph2tm1.2Sna
Genetic
Background		 B6N.Cg-Diaph1tm1.1Sna Diahp2tm1.2Sna
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diaph1tm1.1Sna mutation (0 available); any Diaph1 mutation (116 available)
Diaph2tm1.2Sna mutation (0 available); any Diaph2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:215740 )
N
• layer formation in the somatosensory cortex is normal
abnormal neuronal migration ( J:215740 )
• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)
• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end
• double cortin positive cells are disorganized on the lateral ventricle wall before migration
• migration of cells out of explants cultured in Matrigel is reduced
• migration of cells is slower
abnormal cerebral cortex morphology ( J:215740 )
• fewer GABA cells in the cerebral cortex at E16.5
abnormal olfactory bulb granule cell layer morphology ( J:215740 )
• marked loss of granule cells in adults
small olfactory bulb ( J:215740 )
• reduced in size whereas brain size is normal

cellular
abnormal neuronal migration ( J:215740 )
• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)
• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end
• double cortin positive cells are disorganized on the lateral ventricle wall before migration
• migration of cells out of explants cultured in Matrigel is reduced
• migration of cells is slower




Genotype
MGI:5606189
cx3
Allelic
Composition		 Diaph1tm1.1Sna/Diaph1tm1.1Sna
Diaph2tm1.2Sna/Y
Genetic
Background		 B6N.Cg-Diaph1tm1.1Sna Diahp2tm1.2Sna
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diaph1tm1.1Sna mutation (0 available); any Diaph1 mutation (116 available)
Diaph2tm1.2Sna mutation (0 available); any Diaph2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:215740 )
N
• layer formation in the somatosensory cortex is normal
abnormal neuronal migration ( J:215740 )
• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)
• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end
• double cortin positive cells are disorganized on the lateral ventricle wall before migration
• migration of cells out of explants cultured in Matrigel is reduced
• migration of cells is slower
abnormal cerebral cortex morphology ( J:215740 )
• fewer GABA cells in the cerebral cortex at E16.5
abnormal olfactory bulb granule cell layer morphology ( J:215740 )
• marked loss of granule cells in adults
small olfactory bulb ( J:215740 )
• reduced in size whereas brain size is normal

cellular
abnormal neuronal migration ( J:215740 )
• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)
• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end
• double cortin positive cells are disorganized on the lateral ventricle wall before migration
• migration of cells out of explants cultured in Matrigel is reduced
• migration of cells is slower




Genotype
MGI:5606187
ot4
Allelic
Composition		 Diaph2tm1.2Sna/Y
Genetic
Background		 B6N.Cg-Diaph2tm1.2Sna
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diaph2tm1.2Sna mutation (0 available); any Diaph2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:215740 )
• homozygotes appear to develop normally




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory