Analysis Tools
renal/urinary system
| N |
• no differences in water intake, urinary osmolyte excretion, urinary urea excretion or arginine vasopressin plasma levels
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• on a high salt diet
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• on a high salt diet
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• modest but significant reduction when fluid intake is similar to controls or whwn under moderate water restriction
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• reduced arginine vasopressin stimulated cAMP accumulation in inner medulla collecting ducts
• magnitude of the decrease in arginine vasopressin stimulated inner medullary cAMP and urinary concentrating ability is similar to mice with conditional deletion of Adcy6 alone
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• urine volume tends to be increased when fluid intake is similar to controls and is significantly increased during moderate and severe water restriction
• urine volume is increased in mice on a high salt diet compared to diet matched controls
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cardiovascular system
| N |
• blood pressure is similar to controls
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homeostasis/metabolism
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• on a high salt diet
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• on a high salt diet
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• modest but significant reduction when fluid intake is similar to controls or whwn under moderate water restriction
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