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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pou4f2tm2.1Gan
targeted mutation 2.1, Lin Gan
MGI:5607138
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pou4f2tm2.1Gan/Pou4f2tm2.1Gan
Tg(CAG-cre/Esr1*)5Amc/0 		involves: C57BL/6 * C57BL/6J * CBA MGI:5607145
cn2
 		Pou4f1tm1.1Gan/Pou4f1tm1.1Gan
Pou4f2tm2.1Gan/Pou4f2tm2.1Gan
Tg(CAG-cre/Esr1*)5Amc/0 		Not Specified MGI:5607147


Genotype
MGI:5607145
cn1
Allelic
Composition		 Pou4f2tm2.1Gan/Pou4f2tm2.1Gan
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f2tm2.1Gan mutation (0 available); any Pou4f2 mutation (7 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:215207 )
N
• mice treated with tamoxifen exhibit normal retinal interneurons and Muller glial cells and normal survival of adult retinal ganglion cells




Genotype
MGI:5607147
cn2
Allelic
Composition		 Pou4f1tm1.1Gan/Pou4f1tm1.1Gan
Pou4f2tm2.1Gan/Pou4f2tm2.1Gan
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f1tm1.1Gan mutation (0 available); any Pou4f1 mutation (13 available)
Pou4f2tm2.1Gan mutation (0 available); any Pou4f2 mutation (7 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:215207 )
N
• mice treated with tamoxifen exhibit normal retinal interneurons, Muller glial cells, and optic nerves and normal survival of adult retinal ganglion cells under normal conditions
abnormal eye physiology ( J:215207 )
• death of retinal ganglion cells in tamoxifen treated mice at 3 days post controlled optic nerve crush is initially delayed but this difference is no longer present at 5 days after crush, indicating impaired acute response to damage




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory