Phenotypes associated with this allele

• Allele Symbol: Cers6^tm1Arte
• Allele Name: targeted mutation 1, TaconicArtemis
• Allele ID: MGI:5607416
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cers6^tm1Arte/Cers6^tm1Arte Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * C57BL/6N	MGI:5607428
cn2	Cers6^tm1Arte/Cers6^tm1Arte Tg(Alb1-cre)7Gsc/0	involves: C57BL/6N * FVB/N	MGI:5607429

Genotype
MGI:5607428

cn1

• Allelic Composition: Cers6^tm1Arte/Cers6^tm1Arte; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:215519 )

N • mice fed a high-fat diet do not show differences in body weight or adiposity, or any improvements in glucose metabolism compared to controls

Genotype
MGI:5607429

cn2

• Allelic Composition: Cers6^tm1Arte/Cers6^tm1Arte; Tg(Alb1-cre)7Gsc/0
• Genetic Background: involves: C57BL/6N * FVB/N

growth/size/body

decreased susceptibility to diet-induced obesity ( J:215519 )

• mice fed a high-fat diet are only subtly protected from diet-induced body weight gain

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:215519 )

• mice fed a high-fat diet are only subtly protected from diet-induced body weight gain

improved glucose tolerance ( J:215519 )

• mice fed a high-fat diet show improved glucose tolerance, but not insulin sensitivity

abnormal ceramide level ( J:215519 )

• reduction in hepatic C(16:0) ceramides and dihydroceramides