Phenotypes associated with this allele

• Allele Symbol: Cers6^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5607417
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cers6^tm1.1Arte/Cers6^tm1.1Arte	involves: BALB/cJ * C57BL/6N	MGI:5607426

Genotype
MGI:5607426

hm1

• Allelic Composition: Cers6^tm1.1Arte/Cers6^tm1.1Arte
• Genetic Background: involves: BALB/cJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:215519 )

• mice fed a high-fat diet exhibit decreased body fat content

decreased brown fat cell lipid droplet size ( J:215519 )

• mice fed a high-fat diet exhibit show a reduction in lipid droplet volume in brown adipose tissue

decreased fat cell size ( J:215519 )

• mice fed a high-fat diet exhibit reduced adipocyte size

cellular

abnormal cellular respiration ( J:215519 )

• mice fed a high-fat diet show an elevation in mitochondrial beta-oxidative capacity of brown adipocytes

• however, maximal respiratory chain enzymes' capacities in brown adipose tissue are not different and maximal oxygen consumption rate is normal

increased fatty acid oxidation ( J:215519 )

• mice fed a high-fat diet show increased rates of palmitate oxidation in primary hepatocytes, indicating elevated fatty acid oxidation in liver

growth/size/body

decreased susceptibility to diet-induced obesity ( J:215519 )

• mice are protected from diet-induced obesity, showing reduced body weight, decreased body fat content, reduced adipocyte size and lower serum leptin concentrations than controls

homeostasis/metabolism

increased fatty acid oxidation ( J:215519 )

• mice fed a high-fat diet show increased rates of palmitate oxidation in primary hepatocytes, indicating elevated fatty acid oxidation in liver

decreased circulating insulin level ( J:215519 )

• mice fed a high-fat diet show reduced serum insulin concentrations

decreased circulating leptin level ( J:215519 )

• mice fed a high-fat diet exhibit lower serum leptin concentration

increased energy expenditure ( J:215519 )

• mice fed a high-fat diet show normal locomotor activity and food consumption, indicating an increase in rate of energy expenditure

decreased susceptibility to diet-induced obesity ( J:215519 )

• mice are protected from diet-induced obesity, showing reduced body weight, decreased body fat content, reduced adipocyte size and lower serum leptin concentrations than controls

improved glucose tolerance ( J:215519 )

• mice fed a high-fat diet exhibit improved glucose tolerance and insulin sensitivity

abnormal ceramide level ( J:215519 )

• mice fed a high-fat diet exhibit reduced C(16:0) acyl-chain ceramides in white adipose tissue, brown adipose tissue, and liver, but not in skeletal muscle

• mice fed a high-fat diet exhibit reduced C(14:0) and C(16:0) acyl-chain ceramides in the liver

enhanced lipolysis ( J:215519 )

• mice fed a high-fat diet show a greater stimulated triacylglycerol release from ex vivo brown adipose tissue sections, suggesting increased lipolysis

immune system

decreased inflammatory response ( J:215519 )

• mice fed a high-fat diet are protected from macrophage infiltration and activation of proinflammatory gene expression in white adipose tissue