Phenotypes associated with this allele

• Allele Symbol: Mst1r^{tm2(Mst1r*)Sew}
• Allele Name: targeted mutation 2, Susan E Waltz
• Allele ID: MGI:5607440
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mst1r^tm2(Mst1r*)Sew/Mst1r^tm2(Mst1r*)Sew	FVB.129P2(Cg)-Mst1r^tm2(Mst1r*)Sew	MGI:5607444
hm2	Mst1r^tm2(Mst1r*)Sew/Mst1r^tm2(Mst1r*)Sew	involves: 129P2/OlaHsd * Black Swiss * FVB/N	MGI:5607443

Genotype
MGI:5607444

hm1

• Allelic Composition: Mst1r^{tm2(Mst1r*)Sew}/Mst1r^{tm2(Mst1r*)Sew}
• Genetic Background: FVB.129P2(Cg)-Mst1r^{tm2(Mst1r*)Sew}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating interferon-gamma level ( J:215969 )

• six and fifteen hours following injection of ConA, serum interferon gamma levels are elevated as compared to controls

increased circulating alanine transaminase level ( J:215969 )

• six and fifteen hours following injection of ConA, serum alanine amino transferase levels are elevated as compared to controls

increased susceptibility to xenobiotic induced morbidity/mortality ( J:215969 )

• 100% of mice die 10 hours after exposure to a high dose of ConA, in contrast, no fatalities (post-48 hours) are observed in controls

immune system

increased circulating interferon-gamma level ( J:215969 )

• six and fifteen hours following injection of ConA, serum interferon gamma levels are elevated as compared to controls

increased interferon-gamma secretion ( J:215969 )

• production of interferon gamma is increased in splenocytes in response to ConA stimulation, however, production of other cytokines is not altered

liver/biliary system

hepatic necrosis ( J:215969 )

• mice exhibit necroinflammatory liver injury 14 hours after ConA exposure; controls do not exhibit liver damage

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:215969 )

• 100% of mice die 10 hours after exposure to a high dose of ConA, in contrast, no fatalities (post-48 hours) are observed in controls

Genotype
MGI:5607443

hm2

• Allelic Composition: Mst1r^{tm2(Mst1r*)Sew}/Mst1r^{tm2(Mst1r*)Sew}
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss * FVB/N

hematopoietic system

decreased spleen weight ( J:215969 )

• spleen size is decreased as compared to controls following infection with Friend erythroleukemia virus

immune system

decreased spleen weight ( J:215969 )

• spleen size is decreased as compared to controls following infection with Friend erythroleukemia virus

increased susceptibility to Retroviridae infection ( J:215969 )