Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cnot3tm1.1Tya targeted mutation 1.1, Tadashi Yamamoto MGI:5607530 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice fed a high-fat diet for 12 weeks show that subcutaneous fat depots are greatly decreased in mutants
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• mice fed a high-fat diet for 12 weeks show that visceral fat depots are greatly decreased in mutants
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• weights of adipose tissues are decreased
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• mice fed a high-fat diet for 12 weeks show that visceral fat depots are greatly decreased in mutants
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• smaller body size that is apparent in newborns and remains throughout development
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• at 12 weeks of age, mice weight about 20% less than wild-type mice
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• the nose-anus length is reduced by about 5% at 12 weeks of age
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• mice fed a high-fat diet for 12 weeks become less obese than wild-type mice, with weight of liver, white adipose tissue and brown adipose tissue less than that of wild-type mice on the same diet
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• mice fed a high-fat diet for 12 weeks become less obese than wild-type mice, with weight of liver, white adipose tissue and brown adipose tissue less than that of wild-type mice on the same diet
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• mice fed a high-fat diet for 12 weeks exhibit lower blood glucose levels and remain lower in both glucose tolerance and insulin tolerance tests
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• decrease in blood glucose under fasting conditions
• however, no differences in serum insulin levels
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• decrease in serum triglyceride levels under feeding and fasting conditions
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• whole-body oxygen consumption is higher during dark and light periods, with 24 hour oxygen consumption rates 20% higher than in wild-type mice
• however, rectal temperature is normal
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• glucose tolerance test shows that blood glucose levels remain lower than in wild-type mice after glucose administration
• mice fed a high-fat diet for 12 weeks remain lower in the glucose tolerance test
• however, the insulin response was similar to wild-type mice
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• insulin tolerance test shows a greater decrease in blood glucose levels in mutants than in wild-type mice in response to insulin
• mice are insulin sensitive even on a high-fat diet
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• mice fed a high-fat diet for 12 weeks show that subcutaneous fat depots are greatly decreased in mutants
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• mice fed a high-fat diet for 12 weeks show less fatty liver development than wild-type mice
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• RANKL-induced osteoclastogenesis in bone marrow cells is enhanced, indicating an increase in differentiation into osteoclasts
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• RANKL-induced osteoclastogenesis in bone marrow cells is enhanced, indicating an increase in differentiation into osteoclasts
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• increase in the number of osteoclasts per bone surface and in the levels of osteoclast surface per bone surface
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• RANKL-induced osteoclastogenesis in bone marrow cells is enhanced, indicating an increase in differentiation into osteoclasts
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• increase in the number of osteoclasts per bone surface and in the levels of osteoclast surface per bone surface
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• increase in the number of osteoclasts per bone surface and in the levels of osteoclast surface per bone surface
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• decrease in bone mineral density at 4 months of age
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• aged mice (2 years) show a decrease in cortical bone thickness
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• trabecular bone exhibits a sparse osteoporotic pattern at 4 months of age
• increase in the levels of trabecular separation and trabecular spacing at 4 months of age, which increases with age
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• decrease in trabecular number at 4 months of age
• aging induced osteoporosis results in a 3-fold reduction in the baseline levels of trabecular number compared to 4 month old mutants
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• decrease in trabecular bone mass at 4 months of age
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• trabecular thickness is slightly reduced but is not significant, however aged mice show reduced thickness of trabecular bone
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• decrease in levels of the bone volume per tissue volume at 4 months of age
• osteoporosis is exacerbated with age, with bone volume further reduced by about 50% at 2 years of age, and a further increase in trabecular separation and trabecular spacing and bone resorption
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• elevation in levels of bone formation rate
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• RANKL-induced osteoclastogenesis in bone marrow cells is enhanced, indicating an increase in differentiation into osteoclasts
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• mice show an increase in mineralizing surface per bone surface which represents the number of active osteoblasts per bone surface
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• increase in the number of osteoclasts per bone surface and in the levels of osteoclast surface per bone surface indicating that bone resorption is increased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are less obese than single homozygous Lepob mice
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• oxygen consumption rate is increased and respiratory quotient is lower compared to single homozygous Lepob> mice, indicating greater utilization of fat versus carbohydrates as energy source
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• oxygen consumption rate is increased and respiratory quotient is lower compared to single homozygous Lepob> mice, indicating greater utilization of fat versus carbohydrates as energy source
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• glucose tolerance is ameliorated compared to single homozygous Lepob mice
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• insulin sensitivity is ameliorated compared to single homozygous Lepob mice
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N |
• no differences in locomotor activity or food intake compared to single homozygous Lepob mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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