Phenotypes associated with this allele

• Allele Symbol: Ptbp2^tm1.1Dblk
• Allele Name: targeted mutation 1.1, Douglas Black
• Allele ID: MGI:5607602
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptbp2^tm1.1Dblk/Ptbp2^tm1.1Dblk Emx1^tm1(cre)Ito/Emx1^+	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:5608594
cn2	Ptbp2^tm1.1Dblk/Ptbp2^tm1.1Dblk Tg(Nes-cre)1Kln/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:5608593

Genotype
MGI:5608594

cn1

• Allelic Composition: Ptbp2^tm1.1Dblk/Ptbp2^tm1.1Dblk; Emx1^tm1(cre)Ito/Emx1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:207976 )

• mice die between P18-21

nervous system

enlarged lateral ventricles ( J:207976 )

• enlarged lateral ventricles are observed at both P5 and P11

absent corpus callosum ( J:207976 )

small hippocampus ( J:207976 )

thin cerebral cortex ( J:207976 )

• cortex is thinner than controls

abnormal olfactory bulb layer morphology ( J:207976 )

• lamination of the olfactory bulb is highly disrupted

abnormal mitral cell morphology ( J:207976 )

• olfactory bulb mitral cell layer is absent

neurodegeneration ( J:207976 )

• mice exhibit widespread neuronal death and degeneration

• widespread pyknotic nuclei are observed within the cortical plate

neuron degeneration ( J:207976 )

growth/size/body

decreased body size ( J:207976 )

• small size is observed as early as postnatal day 3

postnatal growth retardation ( J:207976 )

• pups exhibit a slower growth rate than littermates

slow postnatal weight gain ( J:207976 )

• low body weight is observed as early postnatal day 3

• average weight is less than half of controls by P14

Genotype
MGI:5608593

cn2

• Allelic Composition: Ptbp2^tm1.1Dblk/Ptbp2^tm1.1Dblk; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

mortality/aging

neonatal lethality, complete penetrance ( J:207976 )

• pups die within one hour after birth

homeostasis/metabolism

cyanosis ( J:207976 )

nervous system

abnormal brain white matter morphology ( J:207976 )

• major axonal tracts are absent or diminished

abnormal brain commissure morphology ( J:207976 )

• anterior commissure is absent

abnormal brain internal capsule morphology ( J:207976 )

• axonal fiber tracts in the internal and external capsules are reduced

abnormal olfactory tract morphology ( J:207976 )

• lateral olfactory tract is reduced