Phenotypes associated with this allele

• Allele Symbol: Myo5a^d-l34J
• Allele Name: dilute lethal 34 Jackson
• Allele ID: MGI:5607604
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo5a^d-l34J/Myo5a^d-l34J	BALB/cJ-Myo5a^d-l34J/GrsrJ	MGI:5607614
hm2	Myo5a^d-l34J/Myo5a^d-l34J	involves: BALB/cJ * CAST/EiJ	MGI:5607617

Genotype
MGI:5607614

hm1

• Allelic Composition: Myo5a^d-l34J/Myo5a^d-l34J
• Genetic Background: BALB/cJ-Myo5a^d-l34J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

opisthotonus ( J:216055 )

• homozygotes can be seen to tilt their heads to the side, fall over, sprawl on their sides extending their legs together and apart, and curl in an effort to right themselves

ataxia ( J:216055 )

• homozygotes are never able to walk well and they fall, sprawl and have difficulty in righting

impaired balance ( J:216055 )

circling ( J:216055 )

• a few homozygotes display occassional circling

growth/size/body

decreased body size ( J:216055 )

• slightly smaller than normal

mortality/aging

premature death ( J:216055 )

• all homozygotes die by 6 weeks of age

postnatal lethality, incomplete penetrance ( J:216055 )

• most homozygotes die by 4 weeks of age

muscle

opisthotonus ( J:216055 )

• homozygotes can be seen to tilt their heads to the side, fall over, sprawl on their sides extending their legs together and apart, and curl in an effort to right themselves

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Griscelli syndrome type 1		DOID:0060832	OMIM:214450	J:216055

Genotype
MGI:5607617

hm2

• Allelic Composition: Myo5a^d-l34J/Myo5a^d-l34J
• Genetic Background: involves: BALB/cJ * CAST/EiJ

integument

diluted coat color ( J:216055 )

• a diluted coat color can be seen on a non-albino background

pigmentation

diluted coat color ( J:216055 )

• a diluted coat color can be seen on a non-albino background