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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrp3M6Btlr
mutation 6, Bruce Beutler
MGI:5607728
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrp3M6Btlr/Nlrp3M6Btlr C57BL/6J-Nlrp3M6Btlr MGI:5698439
ht2
 		Nlrp3M6Btlr/Nlrp3+ C57BL/6J-Nlrp3M6Btlr MGI:5607729


Genotype
MGI:5698439
hm1
Allelic
Composition		 Nlrp3M6Btlr/Nlrp3M6Btlr
Genetic
Background		 C57BL/6J-Nlrp3M6Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3M6Btlr mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:226677 )
• mice treated with recombinant human myelin oligodendrocyte glycoprotein exhibit reduced disease severity, reduced recruitment of lymphocytes, monocyte-microglia and natural killer cells to the spinal cord compared with wild-type mice




Genotype
MGI:5607729
ht2
Allelic
Composition		 Nlrp3M6Btlr/Nlrp3+
Genetic
Background		 C57BL/6J-Nlrp3M6Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3M6Btlr mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:216047 )
• mice bearing this mutation exhibit attenuated inflammatory responses related to decreased secretion of the proinflammatory cytokine interleukin- (IL-) 1 beta in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment.




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory