Phenotypes associated with this allele

• Allele Symbol: Kcnq3^tm1.1Avtz
• Allele Name: targeted mutation 1.1, Anastasios V Tzingounis
• Allele ID: MGI:5607736
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Emx1^tm1(cre)Krj/? Kcnq3^tm1.1Avtz/Kcnq3^tm1.1Avtz	involves: 129S2/SvPas * C57BL/6	MGI:5607738

Genotype
MGI:5607738

cn1

• Allelic Composition: Emx1^tm1(cre)Krj/?; Kcnq3^tm1.1Avtz/Kcnq3^tm1.1Avtz
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus morphology ( J:208109 )

• hippocampal membrane fractions show reduced KCNQ2 protein levels by about 15% and KCNQ5 protein levels by about 20%

abnormal nervous system electrophysiology ( J:208109 )

• mice show a substantial loss of the M current, however the medium afterhyperpolarization is normal

• CA1 pyramidal neurons tend to show a smaller afterdepolarization, likely due to faster repolarization time course of the afterdepolarization

• KCNQ allosteric activators still markedly dampen neuronal excitability in pyramidal neurons as in controls