Phenotypes associated with this allele

• Allele Symbol: Nfkb1^M1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5607766
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfkb1^M1Btlr/Nfkb1^M1Btlr	C57BL/6J-Nfkb1^M1Btlr	MGI:5607767
ht2	Nfkb1^M1Btlr/Nfkb1^+	C57BL/6J-Nfkb1^M1Btlr	MGI:5608895

Genotype
MGI:5607767

hm1

• Allelic Composition: Nfkb1^M1Btlr/Nfkb1^M1Btlr
• Genetic Background: C57BL/6J-Nfkb1^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased IgG level ( J:216054 )

• mice bearing this mutation exhibit a diminished T cell-dependent IgG response at day 28 following immunization at days 0 and 14 with recombinant Semliki Forest virus- (rSFV-) encoded beta-galactosidase (rSFV-beta-gal); the response of heterozygous mutant mice is intermediate between those of wild-type and homozygous mutant animals.

impaired humoral immune response ( J:216054 )

• mice bearing this mutation exhibit a diminished T cell-dependent IgG response at day 28 following immunization at days 0 and 14 with recombinant Semliki Forest virus- (rSFV-) encoded beta-galactosidase (rSFV-beta-gal); the response of heterozygous mutant mice is intermediate between those of wild-type and homozygous mutant animals.

hematopoietic system

decreased IgG level ( J:216054 )

• mice bearing this mutation exhibit a diminished T cell-dependent IgG response at day 28 following immunization at days 0 and 14 with recombinant Semliki Forest virus- (rSFV-) encoded beta-galactosidase (rSFV-beta-gal); the response of heterozygous mutant mice is intermediate between those of wild-type and homozygous mutant animals.

Genotype
MGI:5608895

ht2

• Allelic Composition: Nfkb1^M1Btlr/Nfkb1⁺
• Genetic Background: C57BL/6J-Nfkb1^M1Btlr

hematopoietic system

decreased IgG level ( J:216054 )

• mice bearing this mutation exhibit a reduced T cell dependent IgG response at day 28 following immunization at days 0 and 14 with recombinant Semliki virus- (rSV-) encoded beta-galactosidase; the response of heterozygous mutant mice is intermediate between those of wild-type and homozygous mutant animals.

immune system

decreased IgG level ( J:216054 )

• mice bearing this mutation exhibit a reduced T cell dependent IgG response at day 28 following immunization at days 0 and 14 with recombinant Semliki virus- (rSV-) encoded beta-galactosidase; the response of heterozygous mutant mice is intermediate between those of wild-type and homozygous mutant animals.

impaired humoral immune response ( J:216054 )

• mice bearing this mutation exhibit a reduced T cell dependent IgG response at day 28 following immunization at days 0 and 14 with recombinant Semliki virus- (rSV-) encoded beta-galactosidase; the response of heterozygous mutant mice is intermediate between those of wild-type and homozygous mutant animals.