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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-RFP,Acr-EGFP)RBGS002Osb
transgene insertion RBGS002, Research Institute for Microbial Diseases, Osaka University
MGI:5607931
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Semg1tm1Kemi/Semg1tm1Kemi
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: 129 * C57BL/6 * C57BL/6N * DBA/2 MGI:5607935
cx2
 		Semg1tm2Kemi/Semg1tm2Kemi
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: 129 * C57BL/6 * C57BL/6N * DBA/2 MGI:5607937
cx3
 		Acrbptm1Tba/Acrbptm1Tba
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: 129S2/SvPas * C57BL/6 * DBA/2 * ICR MGI:7259780
cx4
 		Slc9a8tm1d(KOMP)Wtsi/Slc9a8tm1d(KOMP)Wtsi
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6 * C57BL/6N * DBA/2 MGI:6887369
cx5
 		Lrrc23em1Mngx/Lrrc23em1Mngx
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6 * DBA/2 MGI:6879439
cx6
 		Pdcl2em1Ncvc/Pdcl2em1Ncvc
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6 * DBA/2 MGI:7546844
cx7
 		Nell2em1Osb/Nell2em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6NJcl * DBA/2NJcl MGI:6460305
cx8
 		Gk2em1Osb/Gk2em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6NJcl * DBA/2NJcl MGI:6359880
cx9
 		Cox8cem1Osb/Cox8cem1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6NJcl * DBA/2NJcl MGI:7751120
cx10
 		Cox6b2em1Osb/Cox6b2em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6NJcl * DBA/2NJcl MGI:7751118
cx11
 		Armc12em1Osb/Armc12em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6NJcl * DBA/2NJcl MGI:6513092
tg12
 		Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 involves: C57BL/6 * DBA/2 MGI:5607938


Genotype
MGI:5607935
cx1
Allelic
Composition		 Semg1tm1Kemi/Semg1tm1Kemi
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Semg1tm1Kemi mutation (1 available); any Semg1 mutation (30 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Membrane disruption of intrauterine sperm in Semg1tm1Kemi/Semg1tm1Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 or Semg1tm2Kemi/Semg1tm2Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0

reproductive system
abnormal sperm physiology ( J:207389 )
• intrauterine death of sperm
abnormal sperm motility ( J:207389 )
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla
premature acrosome reaction ( J:207389 )
• ejaculated sperm have already undergone the acrosomal reaction inside the uterus

cellular
abnormal sperm motility ( J:207389 )
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla




Genotype
MGI:5607937
cx2
Allelic
Composition		 Semg1tm2Kemi/Semg1tm2Kemi
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Semg1tm2Kemi mutation (1 available); any Semg1 mutation (30 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Membrane disruption of intrauterine sperm in Semg1tm1Kemi/Semg1tm1Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 or Semg1tm2Kemi/Semg1tm2Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0

cellular
abnormal sperm motility ( J:207389 )
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla

reproductive system
abnormal sperm physiology ( J:207389 )
• intrauterine death of sperm
abnormal sperm motility ( J:207389 )
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla
premature acrosome reaction ( J:207389 )
• ejaculated sperm have already undergone the acrosomal reaction inside the uterus




Genotype
MGI:7259780
cx3
Allelic
Composition		 Acrbptm1Tba/Acrbptm1Tba
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA/2 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrbptm1Tba mutation (0 available); any Acrbp mutation (19 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired sperm migration in female genital tract ( J:294381 )
• 6 h after mating with superovulated wild-type females, a significantly lower number of sperm is present in oviduct regions R1, R2, R3 and R7 (where R1 and R2 correspond to the lower isthmus and R7 corresponds to the ampulla) relative to controls
impaired fertilization ( J:294381 )
• 6 h after mating with superovulated wild-type females, fertilizing sperm present in oviduct region R7 (ampulla) shows a decreased number of sperm type-a (present on the oocyte zona pellucida [ZP] or already fertilized with the oocyte)
• no sperm containing EGFP in the acrosome is observed in R7, as observed in controls
impaired acrosome reaction ( J:294381 )
• male subfertility may be due to incompleteness of the acrosome reaction rather than the reduced number of sperm migrated into the oviduct
impaired sperm-egg recognition ( J:294381 )
• 6 h after mating with superovulated wild-type females, fertilizing sperm present in oviduct region R7 (ampulla) shows increased numbers of sperm type-b (localized within a 100-um distance from the zona pellucida [ZP]) and sperm type-c (present in the cumulus mass but absent within the 100-um distance from the ZP), indicating a reduction in the ability of sperm to recognize unfertilized oocytes in the cumulus mass

cellular
impaired sperm migration in female genital tract ( J:294381 )
• 6 h after mating with superovulated wild-type females, a significantly lower number of sperm is present in oviduct regions R1, R2, R3 and R7 (where R1 and R2 correspond to the lower isthmus and R7 corresponds to the ampulla) relative to controls




Genotype
MGI:6887369
cx4
Allelic
Composition		 Slc9a8tm1d(KOMP)Wtsi/Slc9a8tm1d(KOMP)Wtsi
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA/2
Cell Lines EPD0033_5_A07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc9a8tm1d(KOMP)Wtsi mutation (0 available); any Slc9a8 mutation (108 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm mitochondrial sheath morphology ( J:245977 )
• mature spermatozoa show abnormal mitochondrial distribution: mitochondria are found in sperm heads instead of forming a sheath around the initial part of the sperm tail
absent acrosome ( J:245977 )
• mature spermatozoa isolated from the caudae epididymides lack acrosomes

cellular
abnormal sperm mitochondrial sheath morphology ( J:245977 )
• mature spermatozoa show abnormal mitochondrial distribution: mitochondria are found in sperm heads instead of forming a sheath around the initial part of the sperm tail
absent acrosome ( J:245977 )
• mature spermatozoa isolated from the caudae epididymides lack acrosomes




Genotype
MGI:6879439
cx5
Allelic
Composition		 Lrrc23em1Mngx/Lrrc23em1Mngx
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc23em1Mngx mutation (0 available); any Lrrc23 mutation (28 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
asthenozoospermia ( J:320661 )
• in a uterotubal junction penetration assay, spermatozoa exhibit an inability to pass through the uterotubual junction

cellular
asthenozoospermia ( J:320661 )
• in a uterotubal junction penetration assay, spermatozoa exhibit an inability to pass through the uterotubual junction




Genotype
MGI:7546844
cx6
Allelic
Composition		 Pdcl2em1Ncvc/Pdcl2em1Ncvc
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcl2em1Ncvc mutation (0 available); any Pdcl2 mutation (21 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm flagellum morphology ( J:338084 )
• spermatozoa do not have clear and continuous signaling throughout the entire length of the flagellar midpiece, indicating an issue with flagella formation during spermatogenesis

cellular
abnormal sperm flagellum morphology ( J:338084 )
• spermatozoa do not have clear and continuous signaling throughout the entire length of the flagellar midpiece, indicating an issue with flagella formation during spermatogenesis




Genotype
MGI:6460305
cx7
Allelic
Composition		 Nell2em1Osb/Nell2em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nell2em1Osb mutation (2 available); any Nell2 mutation (46 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular

reproductive system




Genotype
MGI:6359880
cx8
Allelic
Composition		 Gk2em1Osb/Gk2em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gk2em1Osb mutation (2 available); any Gk2 mutation (20 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired fertilization ( J:278674 )
• impaired passage of sperm through uterotubal junction




Genotype
MGI:7751120
cx9
Allelic
Composition		 Cox8cem1Osb/Cox8cem1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cox8cem1Osb mutation (0 available); any Cox8c mutation (8 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:345850 )
N
• cauda epididymal sperm show no abnormalities in mitochondrial sheath formation




Genotype
MGI:7751118
cx10
Allelic
Composition		 Cox6b2em1Osb/Cox6b2em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cox6b2em1Osb mutation (0 available); any Cox6b2 mutation (13 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:345850 )
N
• cauda epididymal sperm show no abnormalities in mitochondrial sheath formation




Genotype
MGI:6513092
cx11
Allelic
Composition		 Armc12em1Osb/Armc12em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Armc12em1Osb mutation (2 available); any Armc12 mutation (24 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
impaired sperm migration in female genital tract ( J:302631 )
• sperm do not pass through the uterotubual junction

reproductive system
impaired sperm migration in female genital tract ( J:302631 )
• sperm do not pass through the uterotubual junction




Genotype
MGI:5607938
tg12
Allelic
Composition		 Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:216056 )
N
• males are fertile




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory