reproductive system
N |
• the seminal vesicle epithelium morphology appears similar to controls
• fertilization in an in vitro fertilization assay rates of fertilized eggs are comparable to controls
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• strongly reduced fertility with homozygous males siring an average litter size of 0.63 +/- 0.13 pups compared to 5.23 +/- 0.53 and 4.96 +/- 0.42 pups for wild-type and heterozygous mice, respectively
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• intrauterine death of sperm
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behavior/neurological
• copulatory plugs are not formed in female mice mated with homozygous males
• however, mating behavior is normal, sperm are normally produced and rates of motile and hyperactivated sperm are indistinguishable from controls
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