Phenotypes associated with this allele

• Allele Symbol: Plcl1^tm1.1Matk
• Allele Name: targeted mutation 1.1, Matilda Katan
• Allele ID: MGI:5607951
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plcl1^tm1.1Matk/Plcl1^tm1.1Matk	FVB.Cg-Plcl1^tm1.1Matk	MGI:5607953
hm2	Plcl1^tm1.1Matk/Plcl1^tm1.1Matk	involves: C57BL/6 * FVB	MGI:5607954
cn3	Kras^tm4Tyj/Kras^+ Plcl1^tm1.1Matk/Plcl1^tm1.1Matk	involves: 129S4/SvJae * C57BL/6	MGI:5607955

Genotype
MGI:5607953

hm1

• Allelic Composition: Plcl1^tm1.1Matk/Plcl1^tm1.1Matk
• Genetic Background: FVB.Cg-Plcl1^tm1.1Matk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increase in TPA-induced skin proliferation in Plcl1^tm1.1Matk/Plcl1^tm1.1Matk and Plcl1^tm2.1Matk/Plcl1^tm2.1Matk mice

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:207384 )

• Background Sensitivity: increased mortality in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model for mice on an inbred FVB background but not in mice on a mixed C57BL/6 and FVB background

neoplasm

increased incidence of tumors by chemical induction ( J:207384 )

• increase in tumor incidence and volume in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model

increased tumor growth/size ( J:207384 )

• increase in tumor volume in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model

integument

epidermal hyperplasia ( J:207384 )

• higher basal proliferation rate

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:207384 )

• Background Sensitivity: increased mortality in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model for mice on an inbred FVB background but not in mice on a mixed C57BL/6 and FVB background

increased incidence of tumors by chemical induction ( J:207384 )

• increase in tumor incidence and volume in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model

Genotype
MGI:5607954

hm2

• Allelic Composition: Plcl1^tm1.1Matk/Plcl1^tm1.1Matk
• Genetic Background: involves: C57BL/6 * FVB

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:207384 )

• increase in tumor incidence in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model

mortality/aging

mortality/aging ( J:207384 )

N • Background Sensitivity: increased mortality in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model for mice on an inbred FVB background but not in mice on a mixed C57BL/6 and FVB background

neoplasm

increased incidence of tumors by chemical induction ( J:207384 )

• increase in tumor incidence in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model

Genotype
MGI:5607955

cn3

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Plcl1^tm1.1Matk/Plcl1^tm1.1Matk
• Genetic Background: involves: 129S4/SvJae * C57BL/6

neoplasm

increased tumor incidence ( J:207384 )

• lung tumor incidence in ad-cre infected mice is similar to Kras mutant mice wild-type for Plcl1