All Phenotypes Otx2<tm9Sia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Otx2^tm9Sia
targeted mutation 9, Shinichi Aizawa
MGI:5608495

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm9Sia/Otx2^tm9Sia	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5608497
ht2	Otx2^tm1Sia/Otx2^tm9Sia	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5608498

Allelic Composition	Otx2^tm9Sia/Otx2^tm9Sia
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm9Sia mutation (0 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal embryonic neuroepithelium morphology ( J:207608 )

• diencephalic and mesencephalic regions are reduced at E9.5 but are nearly recovered by E12.5

abnormal forebrain morphology ( J:207608 )

• small telencephalic vesicle at E9.5 but nearly recovered by E12.5

embryo

abnormal embryonic neuroepithelium morphology ( J:207608 )

• diencephalic and mesencephalic regions are reduced at E9.5 but are nearly recovered by E12.5

Allelic Composition	Otx2^tm1Sia/Otx2^tm9Sia
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm1Sia mutation (1 available); any Otx2 mutation (50 available)
Otx2^tm9Sia mutation (0 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal embryonic neuroepithelium morphology ( J:207608 )

• diencephalic and mesencephalic regions are reduced

• reduction is more severe than in mice homozygous for Otx2^tm9Sia

abnormal forebrain morphology ( J:207608 )

• small telencephalic vesicle at E9.5

• reduction is more severe than in mice homozygous for Otx2^tm9Sia

embryo

abnormal embryonic neuroepithelium morphology ( J:207608 )

• diencephalic and mesencephalic regions are reduced

• reduction is more severe than in mice homozygous for Otx2^tm9Sia

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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