Phenotypes associated with this allele

• Allele Symbol: Hprt1^{tm1(CAG-Glra3*)Jcme}
• Allele Name: targeted mutation 1, Jochen C Meier
• Allele ID: MGI:5608589
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hprt1^tm1(CAG-Glra3*)Jcme/Y Pvalb^tm1(cre)Arbr/Pvalb^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:5608591
cn2	Hprt1^tm1(CAG-Glra3*)Jcme/Y Tg(Camk2a-cre)2Gsc/0	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:5608590

Genotype
MGI:5608591

cn1

• Allelic Composition: Hprt1^{tm1(CAG-Glra3*)Jcme}/Y; Pvalb^tm1(cre)Arbr/Pvalb⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:207981 )

♂ • amplitudes of evoked field potentials are reduced in CA1 slices

♂ • the power of gamma oscillations in hippocampal subfield CA1 is reduced

♂ • require a higher concentration of bicuculline methiodide to induce pathological activity

abnormal CNS synaptic transmission ( J:207981 )

♂ • bidirectional synaptic plasticity is compromised

absent long-term depression ( J:207981 )

♂ • could not be elicited

behavior/neurological

behavior/neurological phenotype ( J:207981 )

♂N • performance is similar to controls in discriminative associative learning and memory tests

increased anxiety-related response ( J:207981 )

♂ • in light/dark preference, open field and elevated plus maze tests

Genotype
MGI:5608590

cn2

• Allelic Composition: Hprt1^{tm1(CAG-Glra3*)Jcme}/Y; Tg(Camk2a-cre)2Gsc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

nervous system

nervous system phenotype ( J:207981 )

♂N • no difference in long term potentiation/depression ratio

increased susceptibility to pharmacologically induced seizures ( J:207981 )

♂ • at 40 and 60 minutes after kainate injection

abnormal nervous system electrophysiology ( J:207981 )

♂ • the power of gamma oscillations in hippocampal subfield CA1 is reduced

♂ • the latency to pathological activity following disinhibition with bicuculline methiodide is shorter compared to controls

♂ • with increased network excitability, gamma oscillation was consistently disrupted by EPSPs in slices

abnormal synaptic glutamate release ( J:207981 )

♂ • increased release

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:207981 )

♂ • at 40 and 60 minutes after kainate injection

abnormal object recognition memory ( J:207981 )

♂ • impaired ability to discriminate familiar and novel objects

abnormal spatial reference memory ( J:207981 )

♂ • impaired in a reward based 8-arm radial maze test (make more errors when only 50% of the arms are baited)

abnormal spatial working memory ( J:207981 )

♂ • impaired in a reward based 8-arm radial maze test (increase in the number of revisiting events across all trials)