Phenotypes associated with this allele

• Allele Symbol: Ifitm5^tm1Nha
• Allele Name: targeted mutation 1, Nobutaka Hanagata
• Allele ID: MGI:5608595
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifitm5^tm1Nha/Ifitm5^tm1Nha	C57BL/6-Ifitm5^tm1Nha	MGI:5608596

Genotype
MGI:5608596

hm1

• Allelic Composition: Ifitm5^tm1Nha/Ifitm5^tm1Nha
• Genetic Background: C57BL/6-Ifitm5^tm1Nha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:215966 )

• some offspring from intercrosses of homozygous mice die within 48 hours

prenatal lethality, incomplete penetrance ( J:215966 )

• fewer than the expected numbers (only 7% vs. the expected 25%) of homozygotes are seen

• fewer females are seen than males (2 of 8 were female)

reproductive system

decreased litter size ( J:215966 )

• intercrosses of homozygotes result in an average of 1.0 pup per litter

skeleton

abnormal skeleton morphology ( J:215966 )

• skeletons of newborns are shorter

abnormal cranium morphology ( J:215966 )

• newborns exhibit thinner craniums

• however, no difference in cranium size is seen in 40-51 week old mutants

thin frontal bone ( J:215966 )

• thinner frontal bone in newborns

abnormal mandible morphology ( J:215966 )

• newborns exhibit less calcification in the mandible

• however, no differences in mandible are seen in 40-51 week old mutants

abnormal premaxilla morphology ( J:215966 )

• newborns exhibit less calcification in incisive bones and cranial incisors

• however, these differences are no longer seen in 40-51 week old mice

bowed radius ( J:215966 )

• radius is often severely bent in newborns

• however, this bending is no longer obvious in adults

bowed ulna ( J:215966 )

• ulna is often severely bent in newborns

• however, this bending is no longer obvious in adults

bowed tibia ( J:215966 )

• however, this bending is no longer obvious in adults

• trabecular bones of the tibia do not differ from controls

• tibia is often severely bent in newborns

abnormal clavicle morphology ( J:215966 )

• clavicles are bent, often severely, in newborns

• however, this bending is no longer obvious is adults

small clavicle ( J:215966 )

• smaller clavicles in newborns

decreased length of long bones ( J:215966 )

• long bones are about 15-25% shorter in newborns, with both the metaphysis and diaphysis reduced in length

• long bones are 4-12% shorter in 40 to 51 week old mutants

abnormal ilium body morphology ( J:215966 )

• smaller iliac bodies in newborns

• iliac bodies are bent, often severely, in newborns

• however, this bending is no longer obvious is adults

craniofacial

abnormal cranium morphology ( J:215966 )

• newborns exhibit thinner craniums

• however, no difference in cranium size is seen in 40-51 week old mutants

thin frontal bone ( J:215966 )

• thinner frontal bone in newborns

abnormal mandible morphology ( J:215966 )

• newborns exhibit less calcification in the mandible

• however, no differences in mandible are seen in 40-51 week old mutants

abnormal premaxilla morphology ( J:215966 )

• newborns exhibit less calcification in incisive bones and cranial incisors

• however, these differences are no longer seen in 40-51 week old mice

limbs/digits/tail

bowed radius ( J:215966 )

• radius is often severely bent in newborns

• however, this bending is no longer obvious in adults

bowed ulna ( J:215966 )

• ulna is often severely bent in newborns

• however, this bending is no longer obvious in adults

bowed tibia ( J:215966 )

• tibia is often severely bent in newborns

• however, this bending is no longer obvious in adults

• trabecular bones of the tibia do not differ from controls