Phenotypes associated with this allele

• Allele Symbol: Rhoj^tm1.1Auem
• Allele Name: targeted mutation 1.1, Akiyoshi Uemura
• Allele ID: MGI:5608668
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rhoj^tm1.1Auem/Rhoj^tm1.1Auem Tg(Cdh5-cre/ERT2)1Rha/0	involves: C57BL/6 * CBA/JNCrlj	MGI:5608673

Genotype
MGI:5608673

cn1

• Allelic Composition: Rhoj^tm1.1Auem/Rhoj^tm1.1Auem; Tg(Cdh5-cre/ERT2)1Rha/0
• Genetic Background: involves: C57BL/6 * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor vascularization ( J:208154 )

• decrease in vascular densities in peri- and intratumoral areas, decreased pericyte and basement membrane coverage and increased vascular permeability in tumors formed by injection of Lewis lung carcinoma cells

abnormal tumor morphology ( J:208154 )

• tumors formed by injection of Lewis lung carcinoma cells show an increase in hemorrhagic necrosis

decreased tumor growth/size ( J:208154 )

• decreased growth of injected Lewis lung carcinoma cells

• decrease in growth is less than in mice with a germ line deletion of Rhoj

cardiovascular system

abnormal tumor vascularization ( J:208154 )

• decrease in vascular densities in peri- and intratumoral areas, decreased pericyte and basement membrane coverage and increased vascular permeability in tumors formed by injection of Lewis lung carcinoma cells

internal hemorrhage ( J:208154 )

• tumors formed by injection of Lewis lung carcinoma cells show an increase in hemorrhagic foci