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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpnmbtm1Ari
targeted mutation 1, Kiyoshi Ariizumi
MGI:5608675
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpnmbtm1Ari/Gpnmbtm1Ari C57BL/6-Gpnmbtm1Ari MGI:5608676


Genotype
MGI:5608676
hm1
Allelic
Composition		 Gpnmbtm1Ari/Gpnmbtm1Ari
Genetic
Background		 C57BL/6-Gpnmbtm1Ari
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpnmbtm1Ari mutation (0 available); any Gpnmb mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell physiology ( J:215931 )
• dendritic cells are 2-fold greater activators of T cells than wild-type cells
• however, no gross abnormality or developmental defects are seen in lymphoid organs

neoplasm
decreased tumor growth/size ( J:215931 )
• mice show slower growth of subcutaneously inoculated B16 melanoma growth and fewer metastatic foci than in controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory