All Phenotypes Rin3<tm1.1(KOMP)Vlcg> MGI Mouse

abnormal osteoblast physiology ( J:358899 )

• in culture, primary osteoblasts isolated from calvarial bones of 2-day-old mice show a slight but significant increase in mineralized nodule formation

• however, alkaline phosphatase activity in calvarial osteoblasts is normal

abnormal osteoclast morphology ( J:358899 )

• osteoclast surface / bone surface (Oc.S/BS%) is significantly decreased at 8 weeks, but not at 52 weeks, of age

• in culture, M-CSF and RANKL-induced osteoclast formation is normal in terms of total osteoclast number and large osteoclast formation; also, no change in osteoclast survival is seen at any timepoint after RANKL withdrawal

decreased internal diameter of femur ( J:358899 )

• medullary cavity diameter is significantly reduced at the femoral diaphysis at 52 weeks, but not at 8 weeks, of age

• however, other femoral cortical bone parameters (cortical diameter, bone volume, and cortical thickness) are normal at both ages

abnormal trabecular bone morphology ( J:358899 )

• trabecular bone pattern factor is decreased at the distal femoral and proximal tibial metaphysis at 8 and at 52 weeks of age

• however, no change in trabecular bone pattern factor is noted in the 6th lumbar vertebra at 8 or at 52 weeks of age; trabecular bone thickness is normal at the femoral and tibial metaphysis and in the 6th lumbar vertebra at both ages

increased trabecular bone volume ( J:358899 )

• trabecular bone volume/tissue volume (BV/TV%) is significantly increased at the distal femoral and proximal tibial metaphysis at 8 weeks of age, with an even greater increase noted at 52 weeks of age

• however, trabecular BV/TV% is normal in the 6th lumbar vertebra at both ages

increased bone trabecula number ( J:358899 )

• trabecular number is significantly increased at the distal femoral and proximal tibial metaphysis at 8 weeks of age, with an even greater increase noted at 52 weeks of age

• however, trabecular number is normal in the 6th lumbar vertebra at both ages

decreased bone trabecular spacing ( J:358899 )

• trabecular separation is decreased at the distal femoral and proximal tibial metaphysis at 8 and at 52 weeks of age

• however, trabecular separation is normal in the 6th lumbar vertebra at both ages

increased trabecular bone mass ( J:358899 )

• trabecular bone mass is markedly increased in older mice

increased bone ossification ( J:358899 )

• single labeled perimeter (SL.Pm/B.Pm (%)) is significantly increased at 52 weeks of age

• however, serum levels of PINP (a biochemical marker of bone formation) are normal at 8 and at 52 weeks, and mineral apposition rate (MAR) is normal at both ages

decreased bone resorption ( J:358899 )

• femur medullary cavity diameter is significantly smaller at 52 weeks of age, suggesting a lower rate of endosteal bone resorption

• however, serum levels of CTX-I (a biochemical marker of bone resorption) are normal at 8 and at 52 weeks

abnormal osteoclast morphology ( J:358899 )

• osteoclast surface / bone surface (Oc.S/BS%) is significantly decreased at 8 weeks, but not at 52 weeks, of age

• in culture, M-CSF and RANKL-induced osteoclast formation is normal in terms of total osteoclast number and large osteoclast formation; also, no change in osteoclast survival is seen at any timepoint after RANKL withdrawal

abnormal osteoclast morphology ( J:358899 )

• osteoclast surface / bone surface (Oc.S/BS%) is significantly decreased at 8 weeks, but not at 52 weeks, of age

• in culture, M-CSF and RANKL-induced osteoclast formation is normal in terms of total osteoclast number and large osteoclast formation; also, no change in osteoclast survival is seen at any timepoint after RANKL withdrawal

abnormal osteoblast physiology ( J:358899 )

• in culture, primary osteoblasts isolated from calvarial bones of 2-day-old mice show a slight but significant increase in mineralized nodule formation

• however, alkaline phosphatase activity in calvarial osteoblasts is normal

decreased internal diameter of femur ( J:358899 )

• medullary cavity diameter is significantly reduced at the femoral diaphysis at 52 weeks, but not at 8 weeks, of age

• however, other femoral cortical bone parameters (cortical diameter, bone volume, and cortical thickness) are normal at both ages

growth/size/body region phenotype ( J:358899 )

N	• female mice show normal general appearance and body weight at 8 and at 52 weeks of age

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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