Phenotypes associated with this allele

• Allele Symbol: Mars2^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5608699
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mars2^tm1.1(KOMP)Vlcg/Mars2^tm1.1(KOMP)Vlcg	C57BL/6N-Mars2^tm1.1(KOMP)Vlcg/J	MGI:6262845
hm2	Mars2^tm1.1(KOMP)Vlcg/Mars2^tm1.1(KOMP)Vlcg	C57BL/6N-Mars2^tm1.1(KOMP)Vlcg/JMmucd	MGI:6376459
ht3	Mars2^tm1.1(KOMP)Vlcg/Mars2^+	C57BL/6N-Mars2^tm1.1(KOMP)Vlcg/J	MGI:6262844

Genotype
MGI:6262845

hm1

• Allelic Composition: Mars2^{tm1.1(KOMP)Vlcg}/Mars2^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Mars2^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 11264A-D2

Data Sources

IMPC Data for Mars2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6376459

hm2

• Allelic Composition: Mars2^{tm1.1(KOMP)Vlcg}/Mars2^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Mars2^{tm1.1(KOMP)Vlcg}/JMmucd
• Cell Lines: 11264A-D2

Mars2^{tm1.1(KOMP)Vlcg}/Mars2^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality with embryos recovered at E7.5 but not at E9.5. Embryos are small and form a rudimentary egg-cylinder but a primitive streak and hallmarks of gastrulation are not seen at E7.5.

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered in expected Mendelian ratios at E7.5 but arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:290315 , J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

decreased egg cylinder size ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

Genotype
MGI:6262844

ht3

• Allelic Composition: Mars2^{tm1.1(KOMP)Vlcg}/Mars2⁺
• Genetic Background: C57BL/6N-Mars2^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 11264A-D2

Data Sources

IMPC Data for Mars2

adipose tissue

increased total body fat amount ( J:211773 )

♂

IMPC - JAX

growth/size/body

decreased lean body mass ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

decreased fasting circulating glucose level ( J:211773 )

♀

IMPC - JAX

decreased urine magnesium level ( J:211773 )

IMPC - JAX

renal/urinary system

decreased urine magnesium level ( J:211773 )

IMPC - JAX