All Phenotypes Aldh2<tm1Dmro> MGI Mouse

cardiac hypertrophy ( J:261952 )

• mice fed a high-fat diet to induce diabetes exhibit increased cardiomyocyte hypertrophy compared to diabetic controls

abnormal cardiac output ( J:261952 )

• an increase in cardiac output after exercise stress is seen in both mutant and wild-type diabetic mice, however the increase in this parameter immediately after exercise is lower in mutants

decreased cardiac muscle contractility ( J:261952 )

• % fractional shortening and % ejection fraction are lower in diabetic mutant mice after exercise compared to control diabetic mice, but are not different at rest

abnormal heart rate ( J:261952 )

• an increase in heart rate after exercise stress is seen in both mutant and wild-type diabetic mice, however the increase in this parameter immediately after exercise is lower in mutants

congestive heart failure ( J:261952 )

• mice fed a high-fat diet to induce diabetes exhibit heart failure of preserved ejection fraction, showing diastolic dysfunction but preserved systolic function at rest

impaired exercise endurance ( J:261952 )

• mice fed a high-fat diet to induce diabetes run for a shorter duration and distance than control diabetic mice, indicating lower exercise tolerance

abnormal circulating hormone level ( J:261952 )

• slight increase in serum brain natriuretic peptide levels in diabetic mutants compared to diabetic controls

abnormal ethanol metabolism ( J:215904 )

• mice challenged with ethanol accumulate 5 times higher blood acetaldehyde levels than wild-type mice

abnormal nociception after inflammation ( J:215904 )

• mice injected with carrageen in the hind paw to induce acute inflammatory pain exhibit a larger hyperalgesia response and show a higher accumulation of 4-hydroxynonenal adduct levels in the paw than wild-type mice

• injection of acetaldehyde into the paw lowers the nociceptive threshold and extends the duration of nociceptive behavior compared to wild-type mice

• injection of formalin into the paw results in an extended phase 2 of nociceptive response (30 min longer) of flinching and licking but no differences in phase 1

• administration of the Aldh2 activator Alda-1 reduces the response to the nociceptive stimulus after carrageen injection and reduces the formalin-induced flinching during phase 2 of the response

• however, baseline nociceptive behavior is normal

hyperalgesia ( J:215904 )

• mice injected with carrageen, formalin or acetaldehyde into the paw exhibit a larger hyperalgesia response than wild-type mice

• mice, however show normal activity in the open field, in rearing behavior, and on the rotarod