Phenotypes associated with this allele

• Allele Symbol: Scn11a^tm1Gsk
• Allele Name: targeted mutation 1, GlaxoSmithKline
• Allele ID: MGI:5608917
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn11a^tm1Gsk/Scn11a^tm1Gsk	involves: 129P2/OlaHsd * C57BL/6	MGI:5609010

Genotype
MGI:5609010

hm1

• Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal single cell response ( J:216497 )

• small dorsal root ganglion (DRG) neurons do not display novel and nociceptive currents with inward current density at -60 mV of only -0.3 +/- 0.1 pA/pF

• DRG neurons are no longer capable to generate plateau depolarization in response to brief above threshold depolarizing currents, no longer display intrinsic bursting behavior, and do not display bistable behavior

• neurons fail to show increased excitability in response to exposure to an inflammatory soup