Phenotypes associated with this allele

• Allele Symbol: Cldn4^tm1.1Jhou
• Allele Name: targeted mutation 1.1, Jianghui Hou
• Allele ID: MGI:5609165
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cldn4^tm1.1Jhou/Cldn4^tm1.1Jhou Tg(Aqp2-cre)1Dek/0	B6.Cg-Cldn4^tm1.1Jhou Tg(Aqp2-cre)1Dek	MGI:5609166

Genotype
MGI:5609166

cn1

• Allelic Composition: Cldn4^tm1.1Jhou/Cldn4^tm1.1Jhou; Tg(Aqp2-cre)1Dek/0
• Genetic Background: B6.Cg-Cldn4^tm1.1Jhou Tg(Aqp2-cre)1Dek

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased mean systemic arterial blood pressure ( J:216399 )

• mean blood pressure of anesthetized mice is lower than in controls

• mean blood pressure of unanesthetized and unrestrained males is lower than in control throughout the 24 hour observation period, with a significant difference during the dark cycle

• hypotension is exacerbated by a low-salt diet

homeostasis/metabolism

increased circulating bicarbonate level ( J:216399 )

• arterial bicarbonate levels are higher

increased circulating aldosterone level ( J:216399 )

• mice fed a low-salt diet exhibit higher plasma aldosterone levels than those on a regular diet

increased circulating potassium level ( J:216399 )

• plasma potassium shows a trend toward hyperkalemia however, renal handling of potassium is normal

decreased circulating chloride level ( J:216399 )

• plasma chloride levels are lower in 10-12 week old mice

• mice fed a low-salt diet maintain the hypochloremia that is seen on a regular diet

increased urine chloride ion level ( J:216399 )

• renal loss of chloride, with fractional excretion of chloride increased by 1.79-fold and absolute excretion of chloride increased by 1.96-fold

• mice fed a low-salt diet maintain the chloriuresis that is seen on a regular diet

abnormal renal sodium reabsorption ( J:216399 )

• the reduction of urinary sodium excretion is slower in mutants from regular to low-salt diet, indicating defects in low-salt-induced renal reabsorption

increased urine sodium level ( J:216399 )

• renal loss of sodium, with fractional excretion increased by 1.52-fold and absolute excretion increased by 1.66-fold

• mice fed a low-salt diet maintain the natriuresis that is seen on a regular diet

alkalosis ( J:216399 )

• arterial bicarbonate levels are higher, however arterial pH is maintained at similar levels to controls, indicating compensated metabolic alkalosis

renal/urinary system

increased urine chloride ion level ( J:216399 )

• renal loss of chloride, with fractional excretion of chloride increased by 1.79-fold and absolute excretion of chloride increased by 1.96-fold

• mice fed a low-salt diet maintain the chloriuresis that is seen on a regular diet

increased urine sodium level ( J:216399 )

• renal loss of sodium, with fractional excretion increased by 1.52-fold and absolute excretion increased by 1.66-fold

• mice fed a low-salt diet maintain the natriuresis that is seen on a regular diet

abnormal renal reabsorption ( J:216399 )

• the reduction of urinary salt excretion (chloride and sodium) is slower in mutants from regular to low-salt diet, indicating defects in low-salt-induced renal reabsorption

abnormal renal sodium reabsorption ( J:216399 )

• the reduction of urinary sodium excretion is slower in mutants from regular to low-salt diet, indicating defects in low-salt-induced renal reabsorption

polyuria ( J:216399 )

• urinary volume is higher in 10-12 week old mice

• however, glomerular filtration rates are similar to wild-type mice and urinary osmotic pressure is normal

• mice fed a low-salt diet for 5 days exhibit a more severe urinary volume loss than on a regular diet (53% vs. 31% loss)

growth/size/body

decreased body weight ( J:216399 )

• mice fed a low-salt diet for 5 days show a decrease in body weight

hematopoietic system

increased hematocrit ( J:216399 )

• mice fed a low-salt diet exhibit higher hematocrit levels than on a regular diet