All Phenotypes Ephx2<tm1.1Arte> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ephx2^tm1.1Arte
targeted mutation 1.1, TaconicArtemis
MGI:5609316

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ephx2^tm1.1Arte/Ephx2^tm1.1Arte Tg(Pdgfra-cre)1Clc/0	involves: C57BL/6	MGI:5609318
cn2	Ephx2^tm1.1Arte/Ephx2^tm1.1Arte Tg(GFAP-cre)25Mes/0	involves: C57BL/6 * FVB/N	MGI:5609321

Allelic Composition	Ephx2^tm1.1Arte/Ephx2^tm1.1Arte Tg(Pdgfra-cre)1Clc/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephx2^tm1.1Arte mutation (0 available); any Ephx2 mutation (39 available)
Tg(Pdgfra-cre)1Clc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:208344 )

• significant delay in the radial extension of the vascular plexus from the optic nerve to the periphery and decrease in the number of tip cells and filopodia

abnormal vascular branching morphogenesis ( J:208344 )

• significant delay in the radial extension of the vascular plexus from the optic nerve to the periphery and decrease in the number of tip cells and filopodia

vision/eye

abnormal retina vasculature morphology ( J:208344 )

• significant delay in the radial extension of the vascular plexus from the optic nerve to the periphery and decrease in the number of tip cells and filopodia

Allelic Composition	Ephx2^tm1.1Arte/Ephx2^tm1.1Arte Tg(GFAP-cre)25Mes/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephx2^tm1.1Arte mutation (0 available); any Ephx2 mutation (39 available)
Tg(GFAP-cre)25Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:208344 )

• in the retina the upper capillary layer is less dense and characterized by fewer branching points in central areas and at the leading edge

• however, unlike in germ line deleted mice, no delay in radial extension of the vascular plexus is seen

vision/eye

abnormal retina vasculature morphology ( J:208344 )

• in the retina the upper capillary layer is less dense and characterized by fewer branching points in central areas and at the leading edge

• however, unlike in germ line deleted mice, no delay in radial extension of the vascular plexus is seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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