Phenotypes associated with this allele

• Allele Symbol: Ptprc^m2Btlr
• Allele Name: mutation 2, Bruce Beutler
• Allele ID: MGI:5609786
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprc^m2Btlr/Ptprc^m2Btlr	C57BL/6J-Ptprc^m2Btlr	MGI:5609790

Genotype
MGI:5609790

hm1

• Allelic Composition: Ptprc^m2Btlr/Ptprc^m2Btlr
• Genetic Background: C57BL/6J-Ptprc^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased neutrophil cell number ( J:216796 )

• in the peripheral blood.

increased dendritic cell number ( J:216796 )

• increased frequency of CD11c⁺ dendritic cells in the peripheral blood.

decreased mature B cell number ( J:216796 )

• in the peripheral blood.

decreased B-1a cell number ( J:216796 )

• reduced frequency of B-1a B cells within the peripheral B-1 B cell compartment.

decreased B-2 B cell number ( J:216796 )

• in the peripheral blood.

decreased memory B cell number ( J:216796 )

• reduced frequency of IgM⁺ B cells in the periphery.

increased B-1 B cell number ( J:216796 )

• in the peripheral blood.

increased B-1b cell number ( J:216796 )

• increased frequency of peripheral B-1b B cells in the B-1 B cell compartment.

decreased memory T cell number ( J:216796 )

• reduced frequency of CD44⁺ T cells in the periphery

decreased CD4-positive, alpha-beta memory T cell number ( J:216796 )

• reduced frequency of CD44⁺ CD4⁺ T cells in the periphery.

decreased CD8-positive, alpha-beta memory T cell number ( J:216796 )

• reduced frequency of CD44⁺ CD8⁺ T cells in the periphery.

decreased single-positive T cell number ( J:216796 )

• reduced frequency of CD4⁺ T cells in the peripheral blood.

• reduced frequency of CD8⁺ T cells in the periphery.

• reduced frequency of CD8⁺ T cells in the peripheral CD3⁺ T cell compartment.

• reduced frequency of naive CD8⁺ T cells in the periphery.

increased single-positive T cell number ( J:216796 )

• increased frequency of CD4⁺ T cells in the peripheral CD3⁺ compartment.

immune system

increased neutrophil cell number ( J:216796 )

• in the peripheral blood.

increased dendritic cell number ( J:216796 )

• increased frequency of CD11c⁺ dendritic cells in the peripheral blood.

decreased mature B cell number ( J:216796 )

• in the peripheral blood.

decreased B-1a cell number ( J:216796 )

• reduced frequency of B-1a B cells within the peripheral B-1 B cell compartment.

decreased B-2 B cell number ( J:216796 )

• in the peripheral blood.

decreased memory B cell number ( J:216796 )

• reduced frequency of IgM⁺ B cells in the periphery.

increased B-1 B cell number ( J:216796 )

• in the peripheral blood.

increased B-1b cell number ( J:216796 )

• increased frequency of peripheral B-1b B cells in the B-1 B cell compartment.

decreased memory T cell number ( J:216796 )

• reduced frequency of CD44⁺ T cells in the periphery

decreased CD4-positive, alpha-beta memory T cell number ( J:216796 )

• reduced frequency of CD44⁺ CD4⁺ T cells in the periphery.

decreased CD8-positive, alpha-beta memory T cell number ( J:216796 )

• reduced frequency of CD44⁺ CD8⁺ T cells in the periphery.

decreased single-positive T cell number ( J:216796 )

• reduced frequency of CD4⁺ T cells in the peripheral blood.

• reduced frequency of CD8⁺ T cells in the periphery.

• reduced frequency of CD8⁺ T cells in the peripheral CD3⁺ T cell compartment.

• reduced frequency of naive CD8⁺ T cells in the periphery.

increased single-positive T cell number ( J:216796 )

• increased frequency of CD4⁺ T cells in the peripheral CD3⁺ compartment.

abnormal humoral immune response ( J:216796 )

• diminished T cell-dependent antibody response to ovalbumin administered with aluminum hydroxide.

• diminished T-cell dependent antibody response to recombinant Semliki Forest virus- (rSFB-) encoded beta-galactosidase (rSFV-beta-gal).