Phenotypes associated with this allele

• Allele Symbol: Wfdc1^tm1Bcm
• Allele Name: targeted mutation 1, Baylor College of Medicine, Mouse Center
• Allele ID: MGI:5609943
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wfdc1^tm1Bcm/Wfdc1^tm1Bcm	involves: 129S7/SvEvBrd * C57BL/6	MGI:5609947

Genotype
MGI:5609947

hm1

• Allelic Composition: Wfdc1^tm1Bcm/Wfdc1^tm1Bcm
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell adhesion ( J:216357 )

• stromal cells in vitro show increased adhesion to both fibronectin and laminin, but not to vitronectin, or collagen I or IV

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:216357 )

• stromal cells exhibit elevated MMP-9 activity

enhanced wound healing ( J:216357 )

• mice exhibit an increase in rate of wound closure from days 5 to 7 such that by day 6 and 7, respectively, the wound gap is decreased to 46% and 28% of the starting wound gap compared with a decrease to 62% and 46% of the starting gap in heterozygous controls

• wounds show an elevation and more heterogeneity in macrophage recruitment than in controls

• stromal cells in vitro exhibit increased migration and wound closure in wounding scratch assays in cultures

immune system

decreased susceptibility to Orthomyxoviridae infection ( J:216357 )

• mice infected with influenza A exhibit lower viral titers in lung tissue at 4 days post-infection than controls and an elevation in macrophage recruitment to the lungs at 7-days post-infection, as well as increased deposition of osteopontin, a macrophage chemokine

vision/eye

vision/eye phenotype ( J:216357 )

N • mice do not exhibit overt physiological retinal function abnormalities