All Phenotypes Foxp3<tm2.1(EGFP/cre)Shori> MGI Mouse

endocrine/exocrine glands

pancreas atrophy ( J:234397 )

• pancreas is atrophic and the exocrine structure is almost completely lost

pancreas inflammation ( J:234397 )

• early onset of autoimmune exocrine pancreatitis

• total number of cells and frequencies of CD4+ and CD8+ T cells are higher in pancreas and pancreatic lymph nodes

hematopoietic system

enlarged spleen ( J:234397 )

spleen hyperplasia ( J:234397 )

• increased cellularity of spleen

increased effector memory T-helper cell number ( J:234397 )

• increase in CD4+CD44+ and CD8+CD44+ effector/memory T cells, especially in the pancreatic lymph nodes

• increase in frequencies of both CD4+ and CD8+ T cells, especially those expressing CD44 in the spleen and lymph nodes, indicating an expansion of effector/memory T-cell populations

• the ratios of CD4+CD44+/Treg cells and CD8+CD44+/Treg cells are higher, indicating unbalanced T-cell expansion with dominance of effector/memory T cells versus Treg cells

homeostasis/metabolism

decreased circulating lipase level ( J:234397 )

immune system

pancreas inflammation ( J:234397 )

• early onset of autoimmune exocrine pancreatitis

• total number of cells and frequencies of CD4+ and CD8+ T cells are higher in pancreas and pancreatic lymph nodes

enlarged spleen ( J:234397 )

spleen hyperplasia ( J:234397 )

• increased cellularity of spleen

increased effector memory T-helper cell number ( J:234397 )

• increase in CD4+CD44+ and CD8+CD44+ effector/memory T cells, especially in the pancreatic lymph nodes

• increase in frequencies of both CD4+ and CD8+ T cells, especially those expressing CD44 in the spleen and lymph nodes, indicating an expansion of effector/memory T-cell populations

• the ratios of CD4+CD44+/Treg cells and CD8+CD44+/Treg cells are higher, indicating unbalanced T-cell expansion with dominance of effector/memory T cells versus Treg cells

enlarged lymph nodes ( J:234397 )

lymph node hyperplasia ( J:234397 )

• increased cellularity of lymph nodes

increased susceptibility to autoimmune disorder ( J:234397 )

• mice die from T-cell-mediated autoimmune destruction, especially autoimmune pancreatitis

• presence of mononuclear infiltrates in multiple organs such as the pancreas, liver, lung or heart

• more than 70% of neonatal mice that receive CD4+CD25+ T cells from wild-type mice survive over 3 months without any signs of disease

• neonatal mice that receive CD4+CD25+ T cells from Pdcd1^tm1Hon knock-out mice show no signs of disease

mortality/aging

premature death ( J:234397 )

• all males die within 3 months of age

growth/size/body

enlarged spleen ( J:234397 )

spleen hyperplasia ( J:234397 )

• increased cellularity of spleen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatitis		DOID:4989	OMIM:167800	J:234397

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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