Phenotypes associated with this allele

• Allele Symbol: Igh^{tm3.1(IGH)Vlcg}
• Allele Name: targeted mutation 3.1, Velocigene
• Allele ID: MGI:5609988
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm3.1(IGH)Vlcg/Igh^tm3.1(IGH)Vlcg	involves: 129S6/SvEvTac * C57BL/6N	MGI:5610011
cx2	Igh^tm3.1(IGH)Vlcg/Igh^tm3.1(IGH)Vlcg Igk^tm3.1(IGK)Vlcg/Igk^tm3.1(IGK)Vlcg	involves: 129S6/SvEvTac * C57BL/6N	MGI:5610012

Genotype
MGI:5610011

hm1

• Allelic Composition: Igh^{tm3.1(IGH)Vlcg}/Igh^{tm3.1(IGH)Vlcg}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced male fertility ( J:208619 )

♂ • restoring expression of Adam6a and Adam6b restores male fertility

Genotype
MGI:5610012

cx2

• Allelic Composition: Igh^{tm3.1(IGH)Vlcg}/Igh^{tm3.1(IGH)Vlcg}; Igk^{tm3.1(IGK)Vlcg}/Igk^{tm3.1(IGK)Vlcg}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

reproductive system

reduced male fertility ( J:208619 )

♂ • restoring expression of Adam6a and Adam6b restores male fertility

immune system

immune system phenotype ( J:208620 )

N • normal numbers of B cells, normal lambda/kappa ratios, and secondary lymphoid organs appear similar to controls

N • produce humanized antibodies following immunization