Phenotypes associated with this allele

• Allele Symbol: Pde10a^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:5610034
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pde10a^tm1Dgen/Pde10a^tm1Dgen	involves: C57BL/6J	MGI:5610036

Genotype
MGI:5610036

hm1

• Allelic Composition: Pde10a^tm1Dgen/Pde10a^tm1Dgen
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal latent inhibition of conditioning behavior ( J:216851 )

• mutants do not show differences in conditioning to saccharine when preexposed compared to wild-type mice which show decreased conditioning to saccharine that has been tested before conditioning, indicating a modest impairment of latent inhibition

• however, prepulse inhibition is unaltered

impaired conditioning behavior ( J:216851 )

• in an instrumentally conditioned reinforcement task, mutants show impaired attribution of salience to a reward-predicting tone

• mutants that were rewarded and it was expected for the cue to become salient, show an increase in the number of nose pokes over five trials, suggesting misattribution of salience to cues which should not become salient

nervous system

abnormal action potential ( J:216851 )

• decrease in membrane excitability and spontaneous firing of striatal medium spiny neurons

• decrease in action potentials in response to increased steps of current