Phenotypes associated with this allele

• Allele Symbol: Krt8^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5612829
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Krt8^tm1b(EUCOMM)Hmgu/Krt8^tm1b(EUCOMM)Hmgu	C57BL/6N-Krt8^tm1b(EUCOMM)Hmgu/Ics	MGI:5757299
ht2	Krt8^tm1b(EUCOMM)Hmgu/Krt8^+	C57BL/6N-Krt8^tm1b(EUCOMM)Hmgu/Ics	MGI:5757298

Genotype
MGI:5757299

hm1

• Allelic Composition: Krt8^{tm1b(EUCOMM)Hmgu}/Krt8^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Krt8^{tm1b(EUCOMM)Hmgu}/Ics
• Cell Lines: HEPD0592_4_D04

Data Sources

IMPC Data for Krt8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - ICS

Genotype
MGI:5757298

ht2

• Allelic Composition: Krt8^{tm1b(EUCOMM)Hmgu}/Krt8⁺
• Genetic Background: C57BL/6N-Krt8^{tm1b(EUCOMM)Hmgu}/Ics
• Cell Lines: HEPD0592_4_D04

Data Sources

IMPC Data for Krt8

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - ICS

hematopoietic system

increased neutrophil cell number ( J:211773 )

♂

IMPC - ICS

homeostasis/metabolism

improved glucose tolerance ( J:211773 )

♀

IMPC - ICS

immune system

increased neutrophil cell number ( J:211773 )

♂

IMPC - ICS

nervous system

increased prepulse inhibition ( J:211773 )

♀

IMPC - ICS