Phenotypes associated with this allele

• Allele Symbol: Sox2^tm1.1Knd
• Allele Name: targeted mutation 1.1, Hisato Kondoh
• Allele ID: MGI:5613017
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox2^tm1.1Knd/Sox2^tm1.1Knd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5613021
cx2	Sox2^tm1.1Knd/Sox2^tm1.1Knd Tbx6^tm1Pa/Tbx6^tm1Pa	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5613023

Genotype
MGI:5613021

hm1

• Allelic Composition: Sox2^tm1.1Knd/Sox2^tm1.1Knd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:217059 )

N • spinal cord development proceeds without significant defects

Genotype
MGI:5613023

cx2

• Allelic Composition: Sox2^tm1.1Knd/Sox2^tm1.1Knd; Tbx6^tm1Pa/Tbx6^tm1Pa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

embryo

abnormal neural tube morphology ( J:217059 )

• absence of genes associated with neural tube development in the paraxial compartment concomitant with absence of tubular structures at E9.5

• expression analysis indicates absence of markers for the paraxial mesoderm, intermediate mesoderm and endoderm

• however, unlike mice homozygous for the Tbx6 mutation alone, no ectopic expression of Sox2 is seen in the neural tube

nervous system

abnormal neural tube morphology ( J:217059 )

• absence of genes associated with neural tube development in the paraxial compartment concomitant with absence of tubular structures at E9.5

• expression analysis indicates absence of markers for the paraxial mesoderm, intermediate mesoderm and endoderm

• however, unlike mice homozygous for the Tbx6 mutation alone, no ectopic expression of Sox2 is seen in the neural tube