Phenotypes associated with this allele

• Allele Symbol: Dmrta2^tm1Ejbd
• Allele Name: targeted mutation 1, Eric J Bellefroid
• Allele ID: MGI:5613136
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd	involves: C57BL/6	MGI:5613158

Genotype
MGI:5613158

hm1

• Allelic Composition: Dmrta2^tm1Ejbd/Dmrta2^tm1Ejbd
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:215514 )

• most mice die within hours after birth

nervous system

nervous system phenotype ( J:215514 )

N • normal apoptosis in the dorsal telencephalon

abnormal neuronal precursor proliferation ( J:215514 )

• at E11.5, the number of apical mitotic progenitors is slightly increased with a larger increase in basal mitotic progenitors compared with wild-type cortices

• at E18.5, both apical and basal progenitors are decreased compared to in wild-type cortices

absent choroid plexus ( J:215514 )

abnormal telencephalon morphology ( J:215514 )

• early forebrain defects at E10.5 and E15.5 with absence of invaginations of the medial wall, smaller anlages and absent midline structures

decreased Cajal-Retzius cell number ( J:215514 )

• severely impaired differentiation

abnormal cortical ventricular zone morphology ( J:215514 )

• disorganized with bulges protruding to the pial surface in some cases

abnormal subplate morphology ( J:215514 )

• less well formed than in wild-type mice

• however, the proportional seize of the ventricular zone, subventricular zone and cortical plate are normal

abnormal cerebral hemisphere morphology ( J:215514 )

• anlagen of the cerebral hemispheres is smaller than normal at E10.5

• reduced surface area at E18.5

abnormal hippocampus morphology ( J:215514 )

• poor development of efferent fibers

absent dentate gyrus ( J:215514 )

absent hippocampus ( J:215514 )

abnormal cerebral cortex morphology ( J:215514 )

• poorly differentiated structure and absent caudomedial portion

• defects in mediolateral patterning

abnormal neocortex morphology ( J:215514 )

• abnormal limit of the neocortex with the olfactory bulb

• reduced caudal neocortical regions

thickened cerebral cortex ( J:215514 )

• thick cortical wall at E11.5

• however, size is normal at E14.5

thin cerebral cortex ( J:215514 )

• thin cortical walls at E18.5

• however, size is normal at E14.5

small olfactory bulb ( J:215514 )

• reduced surface area at E18.5

abnormal nervous system tract morphology ( J:215514 )

• severe defects in thalamocortical axon and cortifugal axon

abnormal brain commissure morphology ( J:215514 )

• impairment of axonal tracts crossing the midline

• loss of the connections between the cortex and the thalamus

growth/size/body

decreased body size ( J:215514 )

• in mice that survive at P4 and P90

postnatal growth retardation ( J:215514 )

• in mice that survive at P4 and P90

behavior/neurological

absent gastric milk in neonates ( J:215514 )

• possibly because of an inability to eat

limb grasping ( J:215514 )

cellular

abnormal neuronal precursor proliferation ( J:215514 )

• at E11.5, the number of apical mitotic progenitors is slightly increased with a larger increase in basal mitotic progenitors compared with wild-type cortices

• at E18.5, both apical and basal progenitors are decreased compared to in wild-type cortices